What is the recommended assessment and plan for Post-Exposure Prophylaxis (PEP) for HIV exposure?

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Assessment and Plan for HIV Post-Exposure Prophylaxis (PEP)

HIV PEP should be initiated as soon as possible, ideally within hours but no later than 72 hours after exposure, using a full 28-day course of antiretroviral therapy with TDF + 3TC (or FTC) as the backbone regimen plus a third drug such as LPV/r or ATV/r for all individuals with exposures that have potential for HIV transmission. 1, 2

Initial Assessment

Exposure Risk Evaluation

  • Bodily fluids that pose risk:

    • Blood, blood-stained saliva, breast milk, genital secretions
    • Cerebrospinal, amniotic, peritoneal, synovial, pericardial, or pleural fluids 1
  • Exposure routes warranting PEP:

    • Mucous membrane exposure (sexual exposure, splashes to eye, nose, oral cavity)
    • Parenteral exposures (needlestick, sharps injuries) 1
  • Exposures NOT requiring PEP:

    • When exposed individual is already HIV positive
    • When source is confirmed HIV negative
    • Exposures to tears, non-blood-stained saliva, urine, and sweat 1

Immediate Actions

  1. Provide immediate care to exposure site:

    • Wash wounds and skin with soap and water
    • Flush mucous membranes with water 1
  2. Perform HIV testing of exposed person:

    • Use rapid HIV test that provides results within 2 hours (ideally within 20 minutes)
    • Do not delay PEP initiation while awaiting test results 1, 2

PEP Regimen Selection

Preferred Regimen for Adults and Adolescents

  • Backbone regimen: TDF + 3TC (or FTC) 1, 2
  • Third drug: LPV/r or ATV/r 1
  • Alternative third drugs: RAL, DRV/r, or EFV (avoid EFV in women of childbearing age) 1, 2

Preferred Regimen for Children ≤10 years

  • Backbone regimen: ZDV + 3TC 1
  • Alternative backbones: ABC + 3TC or TDF + 3TC (or FTC) 1
  • Third drug: LPV/r 1
  • Alternative third drugs: ATV/r, RAL, DRV, EFV, or NVP 1

PEP Administration

Timing and Duration

  • Initiate PEP as soon as possible after exposure, ideally within hours 1, 2
  • Complete full 28-day course of antiretroviral drugs 1
  • Provide full 28-day prescription at initial visit rather than starter packs 1

Adherence Support

  • Provide enhanced adherence counseling for all individuals starting PEP 1
  • Discuss potential side effects and management strategies
  • Consider adherence tools: pill boxes, smartphone reminders, check-ins 1

Follow-up and Monitoring

Initial Follow-up

  • Schedule follow-up within 72 hours of exposure for reevaluation 1, 2
  • Reassess exposure risk based on any new information about source
  • Adjust regimen if needed based on source's treatment history or drug resistance 1

Laboratory Monitoring

  • Baseline testing: HIV antibody, hepatitis B and C serology, creatinine, liver enzymes
  • Follow-up HIV testing: at 6 weeks, 3 months, and 6 months post-exposure 1
  • Monitor for drug toxicity: especially in patients with risk factors for kidney injury 2

Special Considerations

  • If source is later determined to be HIV-negative, PEP can be discontinued 2
  • For pregnant individuals, evaluate risk/benefit with special consideration of drug safety in pregnancy 2
  • If exposed person completes PEP for non-occupational exposure, assess for ongoing HIV risk and consider transition to PrEP without interruption 1

Common Pitfalls and Caveats

  1. Delayed initiation: Effectiveness decreases with time; start PEP as soon as possible and never beyond 72 hours 1

  2. Incomplete course: Poor adherence reduces effectiveness; provide full 28-day prescription and adherence support 1

  3. Inadequate follow-up: Ensure follow-up within 72 hours to reassess risk and adjust regimen if needed 1

  4. Failure to consider drug resistance: When source person's virus is known or suspected to be resistant, select drugs to which resistance is unlikely 1

  5. Overlooking transition to PrEP: For individuals with ongoing HIV exposure risk, transition directly from PEP to PrEP without a gap 1

The most recent and highest quality evidence from the World Health Organization (2015) supports a three-drug regimen for all PEP cases, with TDF + 3TC (or FTC) as the backbone plus a third drug, which represents an evolution from earlier guidelines that recommended stratification based on exposure severity 1.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

HIV Post-Exposure Prophylaxis (PEP) Guidelines

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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