Hydrazine Is Not Recommended for Oral Use Due to High Toxicity
Hydrazine is contraindicated for oral administration due to its high toxicity and carcinogenic potential. 1, 2
Understanding Hydrazine
Hydrazine is a highly toxic inorganic liquid primarily used as a propellant in military and aviation industries, not as a medication 1. It should not be confused with hydralazine, which is an FDA-approved antihypertensive medication that can be administered orally.
Key Differences:
- Hydrazine: Industrial chemical, propellant, highly toxic
- Hydralazine: Antihypertensive medication with established oral dosing protocols
Toxicity Profile of Hydrazine
Hydrazine exposure carries significant health risks:
Even small amounts can cause:
- Significant soft tissue injury
- Pulmonary injury
- Seizures
- Coma
- Death 1
Long-term risks:
Medical Evidence Against Oral Use
Recent toxicology data from poison centers confirms that hydrazine exposure primarily occurs in industrial settings and requires immediate decontamination 4. The most common symptoms from even brief exposures include:
- Dyspnea
- Throat irritation
- Cough
- Ocular irritation
- Headache 4
Potential Confusion with Hydralazine
Hydralazine (not hydrazine) is an FDA-approved medication for hypertension with established oral dosing protocols:
- Oral dosing range: 100-200 mg daily in 2-3 divided doses
- Typically initiated at 10-25mg three times daily 5
Management of Accidental Hydrazine Exposure
If accidental exposure to hydrazine occurs:
- Immediate evacuation from the exposure source
- Thorough decontamination
- Symptomatic management focusing on:
Conclusion
Hydrazine is an industrial chemical with no approved medical use for oral administration. It should never be confused with hydralazine, which is a legitimate antihypertensive medication. Any suspected hydrazine exposure should be treated as a medical emergency requiring immediate decontamination and supportive care.