From the Guidelines
Tachycardia is not a commonly reported side effect of Dupixent (dupilumab), which is administered as a subcutaneous injection, not an infusion. Dupixent is a monoclonal antibody that blocks interleukin-4 and interleukin-13 signaling, used to treat conditions like moderate-to-severe atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyps. The most common side effects of Dupixent include injection site reactions, conjunctivitis, blepharitis, oral herpes, keratitis, eye pruritus, and occasionally eosinophilia 1.
Key Points to Consider
- The provided studies do not mention tachycardia as a side effect of Dupixent 1.
- If you're experiencing tachycardia after Dupixent administration, you should contact your healthcare provider immediately as this could represent an uncommon reaction or possibly an allergic response.
- While rare, hypersensitivity reactions can occur with biologic medications like Dupixent and may include symptoms affecting the cardiovascular system.
- Your doctor might need to evaluate whether the tachycardia is related to the medication or has another cause, and they may consider adjusting your treatment plan accordingly.
Important Considerations for Healthcare Providers
- Be aware of the potential for uncommon reactions, including hypersensitivity reactions, in patients receiving Dupixent.
- Monitor patients for signs and symptoms of allergic reactions, including cardiovascular symptoms like tachycardia.
- Consider alternative causes of tachycardia in patients receiving Dupixent and adjust treatment plans as needed.
From the Research
Tachycardia as a Side Effect of Dupixent (Dupilumab) Infusion
- Tachycardia is mentioned as a symptom in one study, where a 48-year-old male patient developed acute myocarditis after receiving one dose of dupilumab for chronic rhinosinusitis with nasal polyps (CRSwNP) 2.
- The patient presented with hypotension, elevated troponin, hypereosinophilia, ST elevation with T wave abnormalities, and a mildly dilated left ventricle with severely reduced systolic function, in addition to tachycardia.
- There is no mention of tachycardia as a side effect in the other studies, which focused on the efficacy and safety of dupilumab in treating various conditions such as asthma, atopic dermatitis, and chronic rhinosinusitis with nasal polyps 3, 4, 5, 6.
- It is worth noting that the study that reported tachycardia as a symptom was a case report of a single patient, and it is unclear whether tachycardia is a common side effect of dupilumab infusion 2.