From the Guidelines
Taking a single dose of ibuprofen 800mg at 35 weeks of pregnancy likely poses minimal risk to your baby, but it's generally not recommended due to potential risks such as premature closure of the ductus arteriosus or reduced amniotic fluid levels, as noted in a study published in the American Family Physician in 2009 1. When considering the use of ibuprofen during pregnancy, it's essential to weigh the potential benefits against the risks. According to the available evidence, NSAIDs like ibuprofen are not known to be teratogenic in humans, but they can cause maternal and fetal effects when used close to term, such as prolonged gestation and labor, increased peripartum blood loss, and increased anemia in the mother, as well as increased cutaneous and intracranial bleeding, premature closure of ductus arteriosus, pulmonary hypertension, impaired renal function, reduced urine output, and reduced amniotic fluid volume in the fetus 1. Some key points to consider when evaluating the risks associated with ibuprofen use during pregnancy include:
- The dose and duration of ibuprofen use, with higher doses and longer durations increasing the risk of adverse effects
- The period of gestation, with use close to term posing a higher risk of complications
- The potential for ibuprofen to displace bilirubin, making it contraindicated in breastfeeding mothers with neonates who have jaundice 1 Given these considerations, it is generally recommended to avoid NSAIDs like ibuprofen after 30 weeks of pregnancy, and instead opt for safer alternatives like acetaminophen (Tylenol) for pain relief. If you have already taken a single dose of ibuprofen 800mg at 35 weeks of pregnancy, it is essential to contact your healthcare provider to discuss any concerns and determine the best course of action for future pain management needs during pregnancy.
From the Research
Fetal Complications with Ibuprofen Use
- The use of ibuprofen during pregnancy, particularly at 35 weeks gestation, may pose risks to the fetus, including premature closure of the fetal ductus arteriosus 2, 3.
- A study reported four cases of prenatal ductus arteriosus constriction, with three patients medicated with either aspirin, metamizole, or ibuprofen during pregnancy, highlighting the potential risk of ibuprofen use 2.
- Another study found that ibuprofen can cause fetal and neonatal adverse effects, including increased risk of premature closure of the fetal ductus arteriosus and oligohydramnios when used after 30 weeks' gestation 3.
Ibuprofen Dosage and Fetal Risks
- The studies do not provide specific information on the likelihood of fetal complications with a single 800mg dose of ibuprofen at 35 weeks gestation.
- However, it is recommended that ibuprofen be used in pregnancy only if the maternal benefits outweigh the potential fetal risks, at the lowest effective dose and for the shortest duration possible 3.