What are the Indian brand names for desmopressin (DDAVP) spray?

Indian Brand Names for Desmopressin Nasal Spray

Based on the available evidence, I cannot provide specific Indian brand names for desmopressin nasal spray as this information is not contained in the provided literature.

Understanding Desmopressin Nasal Spray

Desmopressin (DDAVP) is a synthetic analog of antidiuretic hormone (ADH) vasopressin with enhanced antidiuretic potency, reduced pressor activity, and prolonged duration of action compared to natural vasopressin 1.

Available Formulations

Desmopressin is available in multiple formulations:

• Nasal spray: Administered intranasally at bedtime in doses of 10-40 μg (1-4 sprays) nightly 2, 3
• Oral tablets: 0.2 mg tablets, with doses ranging from 0.2-0.6 mg 3
• Oral melt formulation: 120-240 μg 3
• Parenteral: IV/SC at 0.3-0.4 mcg/kg 3

Clinical Applications

Desmopressin is indicated for:

1. Enuresis: For monosymptomatic nocturnal enuresis in children, particularly those with nocturnal polyuria 2, 3
2. Diabetes insipidus: Treatment of choice for central diabetes insipidus 3, 1
3. Bleeding disorders: Treatment of mild hemophilia A and von Willebrand's disease 3, 1, 4
4. Platelet dysfunction: May be used in patients with inherited or acquired platelet dysfunction 3

Safety Considerations

When prescribing desmopressin nasal spray, be aware of these important safety considerations:

• Hyponatremia risk: Limit evening fluid intake to 200 ml or less with no drinking until morning 3
• Monitoring: Serum sodium levels should be monitored within 1 week and approximately 1 month after starting therapy, then periodically 3
• Intercurrent illness: Consider temporarily suspending desmopressin during illness to prevent water intoxication 3
• Side effects: May include headache, abdominal discomfort, nasal congestion, and rarely water intoxication leading to seizures 2

Dosing for Enuresis

For nocturnal enuresis, the recommended dosing is:

• Nasal spray: 10-40 μg (1-4 sprays) at bedtime 2
• Duration: 10-12 hours, with compensatory polyuria the following day 2

Efficacy Considerations

• Success rates for enuresis treatment range from 10-65%, but relapse rates can be as high as 80% after treatment discontinuation 2
• Factors affecting nasal spray efficacy include nasal congestion, sinusitis, and proper administration technique 2
• Many clinicians now prefer the oral formulations due to more reliable absorption 2, 5

Important Cautions

• Desmopressin is contraindicated in patients with factor VIII levels ≤5% or those with factor VIII antibodies 3
• Use with caution in patients with moderate to severe renal impairment, hyponatremia, or history of hyponatremia 3
• Patients ≥65 years require more frequent monitoring due to increased risk of hyponatremia 3

While I cannot provide the specific Indian brand names for desmopressin nasal spray based on the available evidence, consulting with a local pharmacist or using an Indian drug formulary would be the most reliable way to identify the current market availability of this medication in India.