From the FDA Drug Label
Contraception Use of MOUNJARO may reduce the efficacy of oral hormonal contraceptives. Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation and for 4 weeks after each dose escalation with MOUNJARO [see Drug Interactions (7.2), Use in Specific Populations (8. 3), and Clinical Pharmacology (12.3)].
Yes, oral contraceptives (OCs) may have reduced efficacy in patients taking Mounjaro (tirzepatide) 1. It is recommended that patients using oral hormonal contraceptives switch to a non-oral contraceptive method or add a barrier method of contraception for 4 weeks after initiation and for 4 weeks after each dose escalation with Mounjaro.
From the Research
Oral contraceptives may be less effective while taking Mounjaro (tirzepatide), and it is recommended to consider adding a backup contraceptive method or switching to a non-oral form of contraception. This is because Mounjaro, like other GLP-1 receptor agonists, can delay gastric emptying, which might reduce the absorption of oral medications including birth control pills 2. Additionally, the gastrointestinal side effects of Mounjaro such as nausea, vomiting, or diarrhea could further interfere with proper absorption of oral contraceptives.
Some studies have investigated the interactions between oral contraceptives and other medications, highlighting the importance of considering these interactions to prevent unplanned pregnancies 3, 4, 5. However, the specific interaction between Mounjaro and oral contraceptives is not well-studied. Given the potential for reduced efficacy, it is essential to discuss contraceptive options with a healthcare provider when starting Mounjaro.
The most effective forms of contraception, such as intrauterine devices (IUDs) and implants, have failure rates of less than 1% per year 2. These methods bypass the digestive system and are not affected by Mounjaro's mechanism of action, making them a suitable alternative for women taking this medication. Other non-oral forms of contraception, such as injections or patches, may also be considered.
In summary, the potential interaction between Mounjaro and oral contraceptives highlights the need for careful consideration of contraceptive options in women taking this medication. Using a non-oral form of contraception or adding a backup method can help prevent unplanned pregnancies and ensure effective birth control. Always discuss your contraceptive options with your healthcare provider when starting Mounjaro to develop the most appropriate plan for your specific situation 2.