How do I apply Eucrisa (crisaborole)?

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Last updated: August 25, 2025View editorial policy

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How to Apply Eucrisa (Crisaborole)

Eucrisa (crisaborole) 2% ointment should be applied as a thin layer to affected areas of skin twice daily. 1

Proper Application Technique

  1. Clean the affected area:

    • Gently cleanse the affected skin with warm water or a mild, soap-free cleanser
    • Pat dry (don't rub) with a soft towel
  2. Apply the medication:

    • Use clean hands to apply a thin layer of Eucrisa to affected areas only
    • Apply enough to cover the affected area completely but avoid excessive application
    • Rub in gently until fully absorbed
  3. Wash hands after application:

    • Unless hands are being treated, wash hands thoroughly after applying the ointment

Important Usage Guidelines

  • Frequency: Apply twice daily 1
  • Duration: Continue treatment as prescribed by your healthcare provider (typically for at least 4-8 weeks to see significant improvement)
  • External use only: Eucrisa is for topical use only and should not be used in the eyes, mouth, or vagina 2
  • Affected areas only: Apply only to areas affected by atopic dermatitis (eczema)

Precautions and Best Practices

  • Avoid occlusive dressings: Unless directed by your healthcare provider, don't cover the treated area with bandages or other occlusive materials
  • Monitor for side effects: The most common side effect is application site pain (burning or stinging), which typically resolves with continued use 3
  • Discontinue if irritation worsens: If you experience severe irritation or allergic reaction, discontinue use and contact your healthcare provider

Complementary Skin Care Recommendations

While using Eucrisa, maintain good skin care practices:

  • Use emollients (moisturizers) regularly on unaffected areas
  • Avoid harsh soaps, detergents, and other potential skin irritants 1
  • Avoid excessive washing with hot water 1
  • Consider using urea-containing (5%-10%) moisturizers for general skin care 1

When to Contact Your Healthcare Provider

  • If your condition worsens or shows no improvement after 4-8 weeks of treatment
  • If you develop signs of skin infection (increased redness, warmth, swelling, pus)
  • If you experience severe or persistent application site reactions

Eucrisa offers an effective non-steroidal alternative for treating mild to moderate atopic dermatitis, with clinical studies showing significant improvement in disease severity and pruritus (itching) compared to vehicle alone 4, 3.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Crisaborole Ointment 2%: A Review in Mild to Moderate Atopic Dermatitis.

American journal of clinical dermatology, 2017

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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