Differential Diagnosis
- Single most likely diagnosis
- Burkitt lymphoma: This is the most likely diagnosis given the patient's age, geographic origin, and the histopathological description of the tumor. The presence of medium-sized cells with round nuclei, basophilic cytoplasm, and vacuoles, along with scattered tangible body macrophages and a high proliferation rate, is characteristic of Burkitt lymphoma. The fact that the patient is from Uganda, a region with high endemicity for Burkitt lymphoma, and is non-immunized, further supports this diagnosis.
- Other Likely diagnoses
- Other non-Hodgkin lymphomas (e.g., diffuse large B-cell lymphoma): Although less likely than Burkitt lymphoma, other types of non-Hodgkin lymphoma could present with similar symptoms and histopathological features.
- Ewing's sarcoma: This malignant bone tumor can present with a rapidly growing mass and may have similar histological features, although the presence of vacuoles and tangible body macrophages is more suggestive of Burkitt lymphoma.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
- Rhabdomyosarcoma: Although less likely, this malignant soft tissue tumor can present with a rapidly growing mass and may have similar symptoms. Missing this diagnosis could lead to delayed treatment and poor outcomes.
- Langerhans cell histiocytosis: This rare disorder can present with a variety of symptoms, including masses and bone lesions. Although less likely, it is essential to consider this diagnosis to avoid missing a potentially treatable condition.
- Rare diagnoses
- Other rare lymphomas (e.g., anaplastic large cell lymphoma): These lymphomas are less common and may have similar histopathological features, but are less likely given the patient's age and geographic origin.
- Soft tissue sarcomas (e.g., osteosarcoma, fibrosarcoma): These rare tumors can present with a rapidly growing mass, but are less likely given the histopathological description and the patient's age.