From the Research
To convert Lantus 64 units to Toujeo, you would need approximately 64 * (100/300) = 21-24 units of Toujeo, but the most recent and highest quality study suggests that patients often require a dose adjustment and may need less Toujeo than this calculation suggests, typically ending up at about one-third of their previous Lantus dose 1. When switching from Lantus to Toujeo, the general recommendation is to start with 60-80% of the previous Lantus dose, which in this case would be approximately 38-51 units. However, clinical studies have shown that patients often need less Toujeo than this calculation suggests, typically ending up at about one-third of their previous Lantus dose. Some key points to consider when making this switch include:
- Toujeo is a more concentrated insulin glargine formulation (300 units/mL) compared to Lantus (100 units/mL), making it about three times more potent per volume 2.
- Clinical studies have shown that Toujeo has a lower risk of hypoglycemia, especially at night, and a slightly smaller weight gain compared to Lantus 3.
- The most recent and highest quality study suggests that patients on Gla-300 required significantly more units of insulin daily than the Gla-100 group to achieve equivalent efficacy 1. It's essential to work closely with your healthcare provider when making this switch, as they may recommend starting at a specific dose and then adjusting based on your blood glucose monitoring results. You should monitor your blood glucose levels more frequently during the transition period, as it may take 3-4 days for Toujeo to reach steady-state in your system. Remember that individual responses vary, and your doctor may recommend a different conversion based on your specific medical situation.