What cancers are individuals with a positive Chromo Bioplex (Chromosomal Microarray Bioplex) test prone to?

From the Guidelines

Chromatin bioplex positivity is not a recognized medical condition or biomarker that predicts specific cancer risks. The term "chrom bioplex positive prone" does not have an established definition in oncology, and chromatin complexes (or bioplexes) generally refer to protein assemblies that interact with DNA. If you're concerned about genetic or molecular markers for cancer predisposition, genetic testing panels like BRCA1/2 for breast and ovarian cancers, Lynch syndrome testing for colorectal cancer, or comprehensive genomic profiling would be more appropriate, as they analyze specific genetic mutations or patterns that have established associations with cancer risk 1. For instance, individuals with Lynch Syndrome have a mutation of the MMR gene, which increases the risk of getting certain types of cancer, including colorectal cancer by 80% and endometrial cancer by 60% 1. Other genetic conditions, such as BRCA1 and BRCA2 mutations, also increase the risk of specific cancers, including breast, ovarian, and prostate cancer 1. I recommend consulting with a genetic counselor or oncologist who can provide personalized risk assessment based on your medical history, family history, and appropriate diagnostic testing. Key points to consider include:

• Genetic testing panels can help identify specific genetic mutations or patterns associated with cancer risk
• Lynch syndrome testing can identify individuals at increased risk of colorectal and endometrial cancer
• BRCA1 and BRCA2 mutations can increase the risk of breast, ovarian, and prostate cancer
• Comprehensive genomic profiling can provide a broader understanding of an individual's cancer risk
• Consultation with a genetic counselor or oncologist is essential for personalized risk assessment and management.

From the Research

Cancers Associated with Positive Chromo Bioplex Test

There is no direct evidence in the provided studies that links a positive Chromo Bioplex test to specific cancer risks. However, the studies do discuss various factors associated with the risk of certain cancers:

• Colorectal Cancer:

  • A study published in 2019 2 found that vitamin D concentration was inversely associated with the risk of colorectal cancer, particularly in women.
  • A 2018 study 3 reported lower rates of colorectal cancer among people living with HIV or AIDS.
  • Research from 2024 4 introduced a cell-free DNA blood-based test for colorectal cancer screening, showing 83% sensitivity for detecting colorectal cancer.
  • A 2025 study 5 suggested that a healthy lifestyle can offset the genetic risk of colorectal cancer.

• Breast Cancer:

  • The 2019 study 2 found no inverse association between vitamin D concentration and breast cancer risk.
  • The 2018 study 3 found lower rates of breast cancer among people living with HIV or AIDS.
  • A 2015 study 6 indicated that women with a history of false-positive mammogram results may be at increased risk of developing subsequent breast cancer.

• Prostate Cancer:

  • The 2019 study 2 found no inverse association between vitamin D concentration and prostate cancer risk.
  • The 2018 study 3 reported lower rates of prostate cancer among people living with HIV or AIDS.

Key Findings

• The provided studies do not directly link a positive Chromo Bioplex test to specific cancer risks.
• Various factors, including vitamin D levels, HIV status, and lifestyle, have been associated with the risk of colorectal, breast, and prostate cancers in different studies 2, 3, 4, 6, 5.