Can you receive the Tdap (Tetanus, diphtheria, and pertussis) vaccine and a PPD (Purified Protein Derivative) test at the same time?

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Last updated: August 26, 2025View editorial policy

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Tdap Vaccination and PPD Testing Can Be Administered Simultaneously

Yes, you can receive the Tdap (Tetanus, diphtheria, and pertussis) vaccine and a PPD (Purified Protein Derivative) test at the same time. According to the Advisory Committee on Immunization Practices (ACIP), if two or more vaccines are indicated, they typically should be administered during the same visit 1.

Administration Guidelines

When administering Tdap and PPD simultaneously:

  • Each should be administered at a different anatomic site
  • Use separate syringes for each
  • Some experts recommend administering no more than two injections per muscle, separated by at least one inch 1
  • Administering all indicated vaccines during a single visit increases the likelihood that patients will receive recommended vaccinations 1

Important Considerations

Proper Administration Technique

  • Tdap should be administered as a 0.5 mL intramuscular injection, preferably into the deltoid muscle 1, 2
  • PPD is administered intradermally, which is a different route than Tdap
  • Pay attention to proper labeling as packaging of Tdap vaccines and PPD might appear similar 1

Potential Errors to Avoid

  • If PPD is administered inadvertently instead of Tdap, the person should receive a dose of Tdap 1
  • Be careful to use the correct formulation of Tdap based on age:
    • ADACEL® is licensed for adults aged 19-64 years
    • Both ADACEL® and BOOSTRIX® are licensed for adolescents aged 11-18 years 1

Post-Administration Monitoring

  • Consider observing patients for 15 minutes after vaccination to monitor for syncope (fainting), which may be more common among young adults and adolescents 1, 2
  • This observation period is particularly important when multiple procedures are performed simultaneously

Documentation Requirements

Proper record keeping is essential when administering vaccines:

  • Document the type of vaccine
  • Record the manufacturer
  • Note the anatomic site and route of administration
  • Include the date of administration
  • Document the name of the administering facility 1

By following these guidelines, healthcare providers can safely and effectively administer both Tdap vaccine and PPD testing during the same visit, improving vaccination compliance while maintaining patient safety.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Vaccination Guidelines for Tetanus, Diphtheria, and Pertussis

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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