Peripheral Artery Disease (PAD): This condition is characterized by the narrowing or blockage of the blood vessels outside of the heart, leading to reduced blood flow to the limbs. Intermittent numbness and coldness in the toes, especially during exercise or cold weather, are common symptoms of PAD.

Raynaud's Phenomenon: A condition that affects blood flow to the fingers and toes, and sometimes the ears, nose, and lips. It is characterized by a sudden and temporary narrowing of the arteries in response to cold temperatures or stress, leading to numbness, coldness, and discoloration.
Diabetic Neuropathy: High blood sugar levels can damage the nerves, leading to numbness, tingling, and pain in the feet and toes. Coldness may also be perceived due to impaired nerve function.
Hypothyroidism: An underactive thyroid gland can cause a variety of symptoms, including cold intolerance, numbness, and tingling in the extremities.

Acute Limb Ischemia: A sudden blockage of an artery in the limb, which can lead to severe pain, numbness, coldness, and potentially gangrene if not promptly treated. It is a medical emergency.
Deep Vein Thrombosis (DVT): A blood clot in the deep veins of the legs can cause swelling, pain, and warmth, but in some cases, it may also lead to numbness and coldness due to impaired blood flow.
Aortic Dissection: A tear in the inner layer of the aorta, which can lead to a blockage of blood flow to the limbs, resulting in severe pain, numbness, and coldness.

Erythromelalgia: A rare disorder characterized by burning pain, heat, and redness in the hands and feet, which can sometimes be accompanied by numbness and coldness.
Complex Regional Pain Syndrome (CRPS): A chronic pain condition that can cause numbness, tingling, and changes in skin temperature and color in the affected limb.
Buerger's Disease: A rare disease of the arteries and veins in the arms and legs, which can cause numbness, tingling, and coldness due to impaired blood flow.