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Last updated: August 26, 2025View editorial policy

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Differential Diagnosis for Unilateral Throat Pain when Swallowing

  • Single Most Likely Diagnosis
    • Acute tonsillitis: This condition is characterized by inflammation of the tonsils, often due to bacterial or viral infection. The pain is typically unilateral and worsens with swallowing, making it a prime candidate for the described symptoms.
  • Other Likely Diagnoses
    • Peritonsillar abscess: An accumulation of pus behind the tonsils, which can cause severe, unilateral throat pain that worsens with swallowing.
    • Pharyngitis: Inflammation of the pharynx, which can be caused by viral or bacterial infections, leading to throat pain, especially when swallowing.
    • Dental issues (e.g., abscess, impacted tooth): Referred pain from dental problems can sometimes be felt in the throat, particularly on one side, and may worsen with swallowing due to the proximity of the throat and jaw.
  • Do Not Miss Diagnoses
    • Epiglottitis: Although less common, this condition involves inflammation of the epiglottis and can lead to severe respiratory distress. It requires immediate medical attention.
    • Carotid artery dissection: A tear in the carotid artery can cause neck and throat pain, among other symptoms. It's a medical emergency due to the risk of stroke.
    • Oropharyngeal cancer: Though rare, cancer in the throat area can cause unilateral pain, especially when swallowing. Early detection is crucial for effective treatment.
  • Rare Diagnoses
    • Eagle syndrome: A condition where an elongated styloid process or calcified stylohyoid ligament causes pain in the throat, which can be exacerbated by swallowing.
    • Thyroiditis: Inflammation of the thyroid gland, which can cause throat pain, though it's less commonly associated with swallowing.
    • Esophageal spasm or esophagitis: Conditions affecting the esophagus can cause pain during swallowing, though they are less likely to cause strictly unilateral throat pain.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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