What causes numbness in the axillary (armpit) region of the arm?

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Last updated: March 11, 2025View editorial policy

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Differential Diagnosis for Numbness in Axilla of Arm

  • Single most likely diagnosis
    • Axillary nerve compression or injury: This is a common cause of numbness in the axilla, often due to trauma, compression, or repetitive activities that irritate the axillary nerve.
  • Other Likely diagnoses
    • Brachial plexus neuropathy: This condition can cause numbness, tingling, or weakness in the arm, including the axilla, due to damage or compression of the brachial plexus nerves.
    • Cervical radiculopathy: Nerve root compression or irritation in the cervical spine can cause numbness or tingling in the arm, including the axilla, depending on the specific nerve root affected.
    • Thoracic outlet syndrome: Compression of the nerves or blood vessels in the thoracic outlet can cause numbness, tingling, or weakness in the arm, including the axilla.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Pancoast tumor: A type of lung cancer that can cause numbness, tingling, or weakness in the arm, including the axilla, due to compression of the brachial plexus nerves.
    • Spinal cord injury or compression: Trauma, infection, or tumors affecting the spinal cord can cause numbness, tingling, or weakness in the arm, including the axilla, and require prompt medical attention.
  • Rare diagnoses
    • Sjögren's syndrome: An autoimmune disorder that can cause peripheral neuropathy, including numbness or tingling in the axilla.
    • Vitamin B12 deficiency: A nutritional deficiency that can cause peripheral neuropathy, including numbness or tingling in the axilla.
    • Leprosy: A rare infectious disease that can cause peripheral neuropathy, including numbness or tingling in the axilla.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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