From the FDA Drug Label
Drug Interactions: Caution should be exercised when propranolol hydrochloride extended-release capsules are administered with drugs that have an affect on CYP2D6, 1A2, or 2C19 metabolic pathways Alcohol when used concomitantly with propranolol, may increase plasma levels of propranolol Cardiovascular Drugs: Antiarrhythmics: Propafenone has negative inotropic and beta-blocking properties that can be additive to those of propranolol.
The FDA drug label does not answer the question.
From the Research
Medication Interactions
- The combination of Zofran (ondansetron) and Ativan (lorazepam) has been studied in several clinical trials, with results indicating that this combination is effective in controlling nausea and vomiting caused by chemotherapy 1, 2, 3, 4, 5.
- In one study, the addition of ondansetron to a combination of metoclopramide, dexamethasone, and lorazepam did not improve vomiting prevention in patients receiving high-dose cisplatin, suggesting that the combination of ondansetron and lorazepam may be sufficient for controlling emesis 4.
- Another study compared the combination of ondansetron, dexamethasone, and lorazepam to a combination of metoclopramide, dexamethasone, and lorazepam, and found that the ondansetron combination was significantly superior in controlling emesis and had fewer adverse reactions 5.
- There is no direct evidence in the provided studies regarding the interaction between Zofran (ondansetron), Ativan (lorazepam), and Dramamine (dimenhydrinate) and propranolol.
- However, based on the available evidence, it appears that the combination of Zofran (ondansetron) and Ativan (lorazepam) is safe and effective in controlling nausea and vomiting caused by chemotherapy 1, 2, 3, 4, 5.
Specific Medication Combinations
- Zofran (ondansetron) and Ativan (lorazepam): effective in controlling nausea and vomiting caused by chemotherapy 1, 2, 3, 4, 5.
- Zofran (ondansetron), Ativan (lorazepam), and metoclopramide: did not improve vomiting prevention in patients receiving high-dose cisplatin 4.
- Zofran (ondansetron), dexamethasone, and Ativan (lorazepam): significantly superior to a combination of metoclopramide, dexamethasone, and lorazepam in controlling emesis and had fewer adverse reactions 5.