Treatment Options for Tension Headache
For tension-type headache, a combination of acetaminophen with caffeine is recommended as first-line treatment, with ibuprofen or acetaminophen alone as effective alternatives. 1
First-Line Pharmacologic Treatment
- Acetaminophen with caffeine: Recommended by the American Academy of Family Physicians as first-line treatment due to caffeine's enhancement of analgesic effects 1
- Acetaminophen 1000 mg: Effective and safe option, can be repeated every 6 hours (maximum 4000 mg daily) 1, 2
- Ibuprofen: Recommended by VA/DoD guidelines as equally effective first-line treatment 1, 2
- NSAIDs: Various options (aspirin, diclofenac, naproxen) are effective for tension headache 3
Important Dosing Considerations
- Begin treatment as soon as possible after headache onset
- Limit use of acute medications to no more than twice weekly to prevent medication overuse headache 1
- For patients who don't achieve sufficient pain relief, consider increasing dosage without exceeding maximum daily dose 3
Second-Line Treatment Options
For patients who don't respond to first-line treatments:
- Try a different NSAID or acetaminophen formulation 3
- Consider combination therapy (NSAID plus acetaminophen) for enhanced efficacy 3, 1
Preventive Treatment
Amitriptyline is the most widely researched and recommended prophylactic medication for frequent tension-type headaches:
- Indicated when: Headaches occur more than twice weekly or last more than 2 days 4, 5
- Dosing: Start at low doses (10 mg three times daily with 20 mg at bedtime for elderly/adolescents) 6
- Maintenance: 50-100 mg daily (some patients respond to 40 mg daily) 6
- Monitoring: Watch for anticholinergic side effects, especially in older patients 1
- Duration: Continue maintenance therapy for at least 3 months to reduce relapse risk 6
Non-Pharmacological Approaches
Several evidence-based non-medication options:
- Resting in a dark, quiet room 1
- Adequate hydration 1
- Stress management techniques 1
- Sleep hygiene optimization 1
- Physical therapy and trigger point therapy 1, 7
- Aerobic exercise or progressive strength training 1
Treatment Pitfalls to Avoid
- Medication overuse headache: Occurs when analgesics are used more than twice weekly; monitor frequency of use carefully 1
- Opioids and butalbital: Avoid these medications due to risk of dependency and medication overuse headache 3, 1
- Triptans and ergotamine derivatives: Not first-line for tension headache; contraindicated in patients with CVA history 1
- Neuroimaging: Generally not needed unless headaches have atypical features or are accompanied by new neurological symptoms 1
Headache Monitoring
- Track headache patterns (frequency, severity, duration, response to treatment)
- Identify and avoid potential triggers (alcohol, caffeine, certain foods, stress, fatigue)
- Consider preventive therapy if headaches occur more than twice weekly 1
By following this structured approach to tension headache management, most patients can achieve significant relief while minimizing the risk of medication overuse and other complications.