From the Research
Introduction to ClotPro Reference Values
The ClotPro device is a novel viscoelastic coagulation analyzer used to assess coagulation function in various clinical settings. Understanding the reference values for this device is crucial for healthcare providers to interpret results accurately and make informed decisions.
Comparison with Established Devices
Studies have compared the ClotPro device with established viscoelastic coagulation analyzers, such as ROTEM Delta [ 1, 2, 3 ]. These comparisons aimed to evaluate the correlation between parameters measured by ClotPro and those measured by ROTEM Delta. The findings indicate strong correlations between several parameters, including clot strength and maximal clot firmness.
Key Findings
- Strong correlations were observed between ClotPro and ROTEM Delta parameters, including EX-test vs. EXTEM and IN-test vs. INTEM [ 1 ].
- ClotPro demonstrated high reproducibility in most parameters, whereas ROTEM Delta showed high variability in coagulation times [ 3 ].
- Excellent correlations were observed between ClotPro and ROTEM Delta parameters, including maximal clot firmness [ 2, 3 ].
Reference Values and Clinical Applications
- The establishment of device-specific reference ranges is necessary for accurate interpretation of ClotPro results [ 1, 3 ].
- ClotPro may be used as an alternative to ROTEM Delta for evaluating coagulation function in cardiac surgery, but specific reference ranges need to be established [ 3 ].
- The device has been used to detect enoxaparin and argatroban levels, with strong correlations observed between ClotPro parameters and conventional coagulation tests [ 4 ].
- ClotPro has also been used to detect direct oral anticoagulant levels, with strong correlations observed between ClotPro parameters and plasma drug concentrations [ 5 ].
Treatment and Dosing Considerations
- No specific dosing information is available for the ClotPro device, as it is a diagnostic tool rather than a therapeutic agent.
- However, the device may be used to guide anticoagulation therapy and monitor the effectiveness of treatments such as enoxaparin and argatroban.
Differential Diagnosis and Caveats
- Healthcare providers should be aware of the potential for differences in results between ClotPro and other viscoelastic coagulation analyzers.
- The establishment of device-specific reference ranges is crucial to ensure accurate interpretation of ClotPro results.
- ClotPro results should be interpreted in conjunction with clinical findings and other diagnostic tests to ensure accurate diagnosis and treatment.