From the Guidelines
Hodgkin lymphoma with lymphadenopathy on both sides of the diaphragm is classified as Stage III disease. This staging indicates that the lymphoma has spread to lymph node regions on both sides of the diaphragm, meaning it involves lymph nodes both above and below the diaphragm. The Ann Arbor staging system is used for Hodgkin lymphoma, with stages ranging from I to IV. Stage III specifically denotes disease that has spread to lymph node regions or structures on both sides of the diaphragm, which may include involvement of the spleen.
Key Points to Consider
- The Ann Arbor staging system is the standard classification system used for Hodgkin lymphoma, as described in the studies 1.
- Stage III Hodgkin lymphoma generally has a good prognosis with modern treatment regimens, though specific treatment recommendations would depend on additional factors such as the patient's age, overall health status, and histologic subtype of Hodgkin lymphoma.
- Further evaluation with PET/CT imaging would be important to confirm the extent of disease and to serve as a baseline for assessing treatment response.
Staging Classification
The staging classification for Hodgkin lymphoma is as follows:
- Stage I: Involvement of a single lymphatic region or localized involvement of single extralymphatic organ or site.
- Stage II: Involvement of two or more lymphatic regions on the same side of the diaphragm or localized involvement of a single extralymphatic organ or site and of one or more lymphatic regions on the same side of the diaphragm.
- Stage III: Involvement of lymphatic regions on both sides of the diaphragm.
- Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs with or without lymphatic involvement, as outlined in the studies 1.
Importance of Accurate Staging
Accurate staging is crucial for determining the appropriate treatment approach and predicting outcomes in patients with Hodgkin lymphoma. The Ann Arbor staging system provides a standardized framework for classifying the extent of disease, which helps guide treatment decisions and facilitates communication among healthcare providers, as noted in the study 1.
From the Research
Stage of Hodgkin Lymphoma
The stage of Hodgkin lymphoma with lymphadenopathy on both sides of the diaphragm is:
- Stage III, as indicated by lymph node involvement on both sides of the diaphragm 2
Characteristics of Stage III Hodgkin Lymphoma
Some key characteristics of Stage III Hodgkin lymphoma include:
- Lymph node involvement on both sides of the diaphragm
- May or may not have typical B symptoms such as weight loss, fever, and night sweats
- Requires careful examination and consideration of additional tissue diagnoses in atypical presentations of new masses or lymphadenopathy on the opposite side of the diaphragm 2
Treatment of Hodgkin Lymphoma
Treatment of Hodgkin lymphoma depends on the stage and other factors, and may include: