What are the discharge instructions for a patient who had a panic attack induced by Vyvanse (lisdexamfetamine) and was treated with lorazepam?

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Discharge Instructions for Patient with Vyvanse-Induced Panic Attack Treated with Lorazepam

Patients who experience a panic attack induced by Vyvanse (lisdexamfetamine) and treated with lorazepam should discontinue Vyvanse immediately, monitor for recurrence of anxiety symptoms for 24-48 hours after lorazepam administration, and follow up with their primary care provider within 1 week.

Medication Management

Vyvanse (Lisdexamfetamine)

  • Stop taking Vyvanse immediately until you can discuss with your prescribing physician
  • Amphetamines like Vyvanse can cause tachycardia, hypertension, and anxiety symptoms that may precipitate panic attacks 1
  • Do not restart this medication without consulting your healthcare provider

Lorazepam

  • Take lorazepam only as prescribed for breakthrough anxiety symptoms
  • Typical dosing is 0.5-1 mg every 4-6 hours as needed for anxiety 1
  • Do not exceed prescribed dose or frequency
  • Be aware that benzodiazepines like lorazepam can cause:
    • Drowsiness and sedation
    • Increased risk of falls
    • Potential for dependence with prolonged use 1
  • Do not drive or operate machinery while taking lorazepam
  • Avoid alcohol and other CNS depressants while taking lorazepam

Monitoring Instructions

  • Monitor for recurrence of anxiety symptoms for 24-48 hours after lorazepam administration
  • Watch for signs of respiratory depression, especially if additional doses of lorazepam are taken 1
  • Be aware that even a single dose of lorazepam can have effects lasting 24-72 hours 2
  • If severe anxiety returns after lorazepam wears off, contact your healthcare provider rather than taking additional doses

Warning Signs Requiring Immediate Medical Attention

Seek immediate medical care if you experience:

  • Difficulty breathing or shortness of breath
  • Chest pain or palpitations
  • Severe dizziness or fainting
  • Worsening anxiety despite medication
  • Thoughts of harming yourself or others
  • Confusion or disorientation

Follow-up Care

  • Schedule an appointment with your primary care provider within 1 week
  • Schedule an appointment with your psychiatrist or the provider who prescribed Vyvanse within 2 weeks
  • Bring a list of all medications you are currently taking to your appointments
  • Be prepared to discuss alternative treatment options for your original condition that required Vyvanse

Lifestyle Recommendations

  • Practice stress-reduction techniques such as deep breathing, progressive muscle relaxation, or mindfulness meditation
  • Maintain regular sleep patterns and adequate sleep hygiene
  • Avoid caffeine, energy drinks, and other stimulants that may trigger anxiety
  • Engage in regular physical activity as tolerated, which can help reduce anxiety symptoms
  • Consider cognitive-behavioral therapy (CBT) as a non-pharmacological approach to managing anxiety 3

Additional Information

  • Panic attacks, while frightening, are not life-threatening
  • The combination of stimulants (like Vyvanse) and anxiety disorders increases the risk of panic attacks
  • Benzodiazepines like lorazepam are effective for acute management of panic symptoms but are not recommended for long-term use 4
  • Alternative non-stimulant medications may be considered for your underlying condition

Remember that this was likely a medication-induced panic attack, and proper medication adjustment can prevent future episodes. Follow up with your healthcare providers as recommended to develop an appropriate treatment plan.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Withdrawal, tolerance and sensitization after a single dose of lorazepam.

Pharmacology, biochemistry, and behavior, 1988

Research

Treatment-resistant panic disorder.

CNS spectrums, 2004

Research

Use of benzodiazepines in panic disorder.

The Journal of clinical psychiatry, 1997

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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