Can I restart Mounjaro (tirzepatide) at the same dose of 12.5mg after a 2-week pause?

Restarting Tirzepatide (Mounjaro) After a 2-Week Pause

Yes, you can restart Mounjaro (tirzepatide) at your previous dose of 12.5 mg after a 2-week pause, as this short interruption does not require dose re-titration.

Rationale for Restarting at Previous Dose

• A 2-week interruption is relatively short compared to the half-life and pharmacodynamic effects of tirzepatide
• According to dosing guidelines, re-titration is typically only necessary when patients have missed multiple doses over a longer period 1
• The 12.5 mg dose is within the standard maintenance dose range (5-15 mg), indicating your body has already demonstrated tolerance to this dose level

Considerations When Restarting

Gastrointestinal Tolerance

• Be aware that some gastrointestinal side effects might temporarily recur when restarting, though usually less severe than during initial titration
• Common side effects include:
  • Nausea (37-43%)
  • Diarrhea (22-24%)
  • Vomiting (15-24%)
  • Constipation (12-17%) 1

Monitoring After Restart

• Monitor for any unusual side effects in the first week after restarting
• If significant gastrointestinal symptoms occur:
  • Consider temporary anti-emetic medication if needed
  • Ensure adequate hydration
  • Eat smaller, more frequent meals

When Re-Titration Would Be Necessary

Re-titration from a lower dose would be recommended in these scenarios:

• If the pause had been longer (typically >1 month)
• If you experienced severe side effects at 12.5 mg before the pause
• If you have developed new medical conditions affecting drug metabolism during the pause

Administration Reminders

• Continue to administer subcutaneously in the abdomen, thigh, or upper arm
• Maintain a consistent day of the week for administration
• Can be taken with or without food 1

Long-Term Benefits

Continuing at your established dose of 12.5 mg will help maintain the therapeutic benefits:

• Improved glycemic control
• Weight management benefits
• Reduced risk of diabetes progression 2, 3

Remember that consistency with medication is important for maintaining the metabolic benefits of tirzepatide therapy. If you experience any concerning symptoms after restarting, contact your healthcare provider.