Differential Diagnosis for CK of 391

Single Most Likely Diagnosis

• Muscle Injury or Trauma: A CK (creatine kinase) level of 391 is significantly elevated, suggesting muscle damage. This is the most likely diagnosis, as muscle injury or trauma is a common cause of elevated CK levels.

Other Likely Diagnoses

• Myocardial Infarction: Although the CK level is not extremely high, it could still be indicative of a myocardial infarction, especially if the patient is presenting with other symptoms such as chest pain or ECG changes.
• Muscle Disease (e.g., Muscular Dystrophy): Certain muscle diseases can cause chronically elevated CK levels, and a level of 391 could be seen in these conditions.
• Intensive Exercise: Strenuous exercise, especially if it involves eccentric muscle contractions, can lead to elevated CK levels.

Do Not Miss Diagnoses

• Rhabdomyolysis: Although less likely, rhabdomyolysis is a potentially life-threatening condition that can cause elevated CK levels. It is essential to consider this diagnosis, especially if the patient has a history of trauma, excessive exercise, or certain medications.
• Acute Kidney Injury: Elevated CK levels can also be seen in acute kidney injury, which can be a complication of rhabdomyolysis or other conditions.

Rare Diagnoses

• Neuroleptic Malignant Syndrome: This is a rare but life-threatening condition that can cause elevated CK levels, along with other symptoms such as fever, muscle rigidity, and altered mental status.
• Malignant Hyperthermia: Another rare condition that can cause elevated CK levels, malignant hyperthermia is a medical emergency that requires prompt treatment.