What is the recommended dose of ibuprofen (nonsteroidal anti-inflammatory drug) for a 29-pound infant?

Ibuprofen Dosing for a 29-Pound Infant

For a 29-pound (13.2 kg) infant, the recommended ibuprofen dose is 10 mg/kg every 6-8 hours, which equals approximately 130 mg per dose, not exceeding 40 mg/kg/day. 1

Dosage Calculation

The appropriate dosing for ibuprofen in infants should be weight-based rather than age-based to ensure accuracy:

• Weight of infant: 29 pounds = 13.2 kg
• Recommended dose: 10 mg/kg 1, 2
• Calculated dose: 13.2 kg × 10 mg/kg = 132 mg (rounded to 130 mg)
• Frequency: Every 6-8 hours as needed 2
• Maximum daily dose: 40 mg/kg/day = 528 mg/day 1

Administration Guidelines

• Ibuprofen should be given with food or milk to reduce potential gastrointestinal irritation
• For liquid formulations, use the measuring device provided with the medication for accurate dosing
• Do not exceed 4 doses in 24 hours
• Ensure the child is well-hydrated when receiving ibuprofen 3

Clinical Considerations

Indications

Ibuprofen is appropriate for:

• Fever management (temperature ≥37.8°C)
• Pain relief
• Inflammatory conditions

Efficacy

• Research shows ibuprofen is as effective or more effective than acetaminophen for fever reduction 4
• Maximum temperature reduction occurs 3-4 hours after administration 5
• Duration of action is typically 6-8 hours, longer than acetaminophen 5

Safety Considerations

• Short-term use of ibuprofen is considered safe in infants older than 3 months with body weight above 5-6 kg 1
• Monitor for:
  • Adequate hydration
  • Signs of gastrointestinal discomfort
  • Allergic reactions
  • Renal function if used for extended periods

Common Pitfalls to Avoid

1. Dosing errors: Studies show over 50% of parents misdose antipyretics, with higher error rates for infants under 1 year 6. Always use weight-based dosing.

2. Overdosing: Never exceed the recommended dose or frequency. Excessive dosing can lead to gastrointestinal, renal, or hepatic complications.

3. Underdosing: Using less than the recommended dose may result in inadequate symptom relief.

4. Prolonged use: Ibuprofen should generally be used for short-term symptom management. Consult a healthcare provider if symptoms persist beyond 3 days or worsen.

5. Confusing different formulations: Different concentrations of liquid ibuprofen exist (e.g., infant drops vs. children's liquid). Always check the concentration before administering.

For this 29-pound infant, the 130 mg dose of ibuprofen every 6-8 hours provides an effective and safe option for managing fever and pain while minimizing the risk of adverse effects.