Differential Diagnosis for Burning Pain in the Penis

• Single most likely diagnosis
  • Urethritis: This condition, often caused by sexually transmitted infections (STIs) like gonorrhea or chlamydia, can lead to burning pain during urination and potentially a discharge. The symptoms align closely with the complaint of burning pain in the penis.
• Other Likely diagnoses
  • Urinary Tract Infection (UTI): While more common in women, men can also experience UTIs, which can cause burning pain during urination (dysuria) and pain in the genital area.
  • Prostatitis: Inflammation of the prostate gland can cause pain in the penis, testicles, and perineum, as well as burning during urination.
  • Balanitis: An inflammation of the glans (head) of the penis, often caused by poor hygiene or an allergic reaction, which can lead to burning pain and discomfort.
• Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
  • Testicular Torsion: Although it presents more commonly with acute testicular pain, it's a medical emergency that requires immediate attention. Delayed treatment can result in loss of the testicle.
  • Epididymitis: Inflammation of the epididymis (the tube behind the testicle that stores and carries sperm) can cause severe pain and swelling, and if caused by a bacterial infection, can lead to serious complications if not treated promptly.
  • Penile Fracture: A rare but serious condition that occurs when the penis is injured, often during sexual activity. It requires immediate medical attention to prevent long-term damage.
• Rare diagnoses
  • Peyronie's Disease: A condition characterized by the development of scar tissue inside the penis, leading to curved, painful erections. While not typically associated with burning pain, it can cause penile pain and discomfort.
  • Penile Cancer: A rare type of cancer that can cause pain, discharge, or bleeding from the penis. Early detection is crucial for effective treatment.