From the Research
Vaccinations are not a proven cause of Myasthenia Gravis (MG), and the benefits of vaccination generally outweigh any theoretical risks. While rare case reports have suggested temporal associations between vaccination and the onset or worsening of myasthenia gravis symptoms, these do not prove causation 1, 2, 3, 4, 5. Myasthenia gravis is an autoimmune disorder where the immune system mistakenly attacks acetylcholine receptors at the neuromuscular junction, causing muscle weakness. The exact cause of myasthenia gravis is not fully understood, but it likely results from a combination of genetic and environmental factors.
Key Points to Consider
- Vaccines work by stimulating the immune system, and theoretically, in individuals who are genetically predisposed, this immune stimulation could potentially trigger autoimmune processes.
- However, the risk appears to be extremely low, and the benefits of vaccination generally outweigh any theoretical risks.
- If you have myasthenia gravis and are concerned about vaccines, you should discuss your specific situation with your neurologist, who can provide personalized advice based on your medical history and current condition.
- Most myasthenia gravis patients can safely receive standard vaccinations, though timing them during periods of stable disease may be recommended.
Recent Studies
A recent study published in 2023 found that vaccinations in MG patients have always been debated, but most studies confirm their safety 1. Another study published in 2022 found that inactivated and subunit vaccines are safe and effective in MG, and although some of them, such as anti-SARS-CoV-2 vaccine, might uncommonly cause MG exacerbations, data suggest that benefits still outweigh by far the potential risks 4.
Clinical Implications
In clinical practice, the decision to vaccinate a patient with myasthenia gravis should be made on a case-by-case basis, taking into account the individual's medical history, current condition, and the potential risks and benefits of vaccination. Close follow-up of MG patients is recommended during the post-vaccination period to monitor for any potential adverse effects. Overall, the available evidence suggests that vaccinations are safe for most patients with myasthenia gravis, and the benefits of vaccination in preventing infectious diseases outweigh the potential risks.