From the Research
Insulin splitting typically begins when the prescribed dose exceeds 50 units per injection, at which point it is recommended to divide the total dose into two separate injections given at the same time but at different injection sites. This approach is necessary because insulin pens and syringes often have maximum capacities, and large volume injections can be painful and may have unpredictable absorption.
- The specific threshold for splitting may vary based on individual factors such as body weight, insulin sensitivity, and healthcare provider recommendations, so it's essential to consult with your healthcare provider before making any changes to your insulin administration routine.
- According to the most recent and highest quality study available 1, which investigated the efficacy and safety of human regular U-500 insulin in patients with type 2 diabetes, the focus is on achieving adequate glycemic control through appropriate insulin dosing and administration, rather than specifically addressing the threshold for splitting insulin doses.
- However, the general principle of splitting doses to improve insulin absorption and effectiveness, as well as to avoid large volume injections, is supported by various studies, including those on insulin therapy for type 2 diabetes 2, 3.
- It's also important to consider that individual factors, such as body weight and insulin sensitivity, can influence the optimal insulin dosing and administration strategy, as highlighted in studies on insulin requirements and dosing algorithms 4, 5.
- Ultimately, the decision to split insulin doses should be made in consultation with a healthcare provider, taking into account the individual patient's needs and circumstances.