What causes paresthesia (numbness) in the feet?

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Last updated: March 11, 2025View editorial policy

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Differential Diagnosis for Numbness in Feet

  • Single Most Likely Diagnosis
    • Diabetes Mellitus: This is the most common cause of numbness in the feet, due to peripheral neuropathy caused by high blood sugar levels damaging the nerves.
  • Other Likely Diagnoses
    • Peripheral Artery Disease (PAD): Reduced blood flow to the feet can cause numbness, tingling, and pain.
    • Vitamin B12 Deficiency: A lack of vitamin B12 can cause nerve damage, leading to numbness in the feet.
    • Hypothyroidism: Some people with hypothyroidism may experience numbness or tingling in their feet.
    • Alcohol Abuse: Chronic alcohol abuse can lead to peripheral neuropathy, causing numbness in the feet.
  • Do Not Miss Diagnoses
    • Guillain-Barré Syndrome: A rare autoimmune disorder that can cause rapid onset of numbness, weakness, and paralysis in the feet and legs.
    • Spinal Cord Compression: Compression of the spinal cord can cause numbness, weakness, and paralysis in the feet and legs.
    • Multiple Sclerosis: A chronic autoimmune disease that can cause numbness, weakness, and vision problems.
    • Lyme Disease: A bacterial infection that can cause numbness, weakness, and paralysis in the feet and legs.
  • Rare Diagnoses
    • Charcot-Marie-Tooth Disease: A group of inherited disorders that affect the peripheral nerves, causing numbness, weakness, and muscle wasting in the feet and legs.
    • Fabry Disease: A rare genetic disorder that can cause numbness, tingling, and pain in the feet and hands.
    • Amyloidosis: A rare group of diseases that can cause numbness, weakness, and paralysis in the feet and legs.
    • Sjögren's Syndrome: A rare autoimmune disorder that can cause numbness, tingling, and pain in the feet and hands.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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