From the Guidelines

Limbic encephalitis caused by Systemic Lupus Erythematosus (SLE) is typically treated with glucocorticoids and immunosuppressive therapy.

The treatment approach is based on the principle of managing the underlying inflammatory process and preventing further damage to the brain.
Glucocorticoids, such as prednisone, are often used as the first line of treatment to reduce inflammation and suppress the immune system 1.
Immunosuppressive therapy, such as cyclophosphamide or azathioprine, may be added to the treatment regimen to help control the immune system and prevent further damage to the brain 1.

In cases where limbic encephalitis is associated with generalized lupus activity, the combination of pulse intravenous methylprednisolone and intravenous cyclophosphamide has shown effectiveness in refractory cases 1.
Anti-epileptic drug (AED) therapy may be necessary in patients with seizures, but it is not always required, especially if the seizures are single or infrequent 1.
Anticoagulation therapy may be considered in patients with antiphospholipid antibodies, particularly in cases of thrombotic cerebrovascular disease 1.

The 2019 update of the EULAR recommendations for the management of SLE emphasizes the importance of minimizing glucocorticoid use and using immunomodulatory agents to expedite the tapering or discontinuation of glucocorticoids 1.
Belimumab may be considered as an add-on therapy in patients with persistently active or flaring extrarenal disease, while rituximab may be considered in organ-threatening, refractory disease 1.

From the Research

The treatment for limbic encephalitis caused by SLE includes:

Immunosuppressive treatment, which has been shown to have a satisfactory response in patients with autoimmune limbic encephalitis associated with SLE 2
Immunotherapy, which has been observed to have a good response in patients with limbic encephalitis associated with SLE 2
Methylprednisolone pulse therapy, which has been used to treat a patient with SLE who experienced limbic encephalitis and neurogenic pulmonary edema 3
Antiepileptic treatment, which has been used in combination with methylprednisolone pulse therapy to treat a patient with SLE who experienced limbic encephalitis and seizures 3
Plasma exchange, which has been suggested as a safe and effective option for treating steroid-responsive encephalopathy, including limbic encephalitis associated with SLE, when steroids or other immunosuppressive therapies are ineffective or contraindicated 4

The pathogenesis of limbic encephalitis associated with SLE is poorly understood and may include an autoimmunity component 2, 5
The presence of other surface membrane antibodies should be considered in the search for alternative etiologies 2
High titers of anti-ribosomal-P antibodies in the cerebrospinal fluid may suggest an association with nervous system lupus 6
The diagnosis and management of limbic encephalitis in patients with SLE should be individualized and based on the patient's specific clinical presentation and laboratory findings 2, 5, 3, 6