From the Research
Yes, you can generally continue taking Famotidine while being treated for Small Intestinal Bacterial Overgrowth (SIBO) with Xifaxan (rifaximin). These medications work differently in the body and don't have significant interactions that would prevent their concurrent use. Xifaxan is an antibiotic that targets bacteria in the intestines to treat SIBO, while Famotidine is an H2 blocker that reduces stomach acid production to treat conditions like acid reflux or gastritis.
Treatment Regimen
The standard treatment for SIBO typically involves Xifaxan 550 mg three times daily for 14 days, and this regimen can be followed while maintaining your regular Famotidine dosage (typically 20-40 mg once or twice daily) 1. However, it's worth noting that acid-reducing medications like Famotidine may potentially contribute to SIBO development in some people by reducing the natural acid barrier that helps control bacterial growth. For this reason, your doctor might evaluate whether continuing Famotidine is appropriate for your specific situation.
Efficacy of Rifaximin
Rifaximin has been shown to be effective in treating SIBO, with response rates ranging from 47.4% to 80% in patients with hydrogen-positive or methane-positive breath tests 1. The medication has also been found to be safe and well-tolerated, with no significant adverse effects reported in clinical trials 2.
Considerations
Always consult with your healthcare provider before making any medication changes, as they can provide personalized advice based on your complete medical history. Your doctor may consider alternative treatments or adjustments to your medication regimen to ensure the best possible outcome for your specific condition.
Some key points to consider when taking Famotidine with Xifaxan include: