From the Guidelines

Vancomycin is the best antibiotic for phlebitis, especially in cases where methicillin-resistant staphylococci are suspected.

The choice of antibiotic depends on the severity of the patient's clinical disease, risk factors for infection, and likely pathogens associated with the specific intravascular device 1.
Vancomycin is usually recommended in hospitals or countries with an increased incidence of methicillin-resistant staphylococci due to its activity against coagulase-negative staphylococci and S. aureus 1.
For empirical coverage of CA-MRSA in outpatients with SSTI, oral antibiotic options include vancomycin, clindamycin, TMP-SMX, a tetracycline, and linezolid 1.
The use of vancomycin at 5 mg/mL is more efficacious than at 1 mg/mL in eradicating staphylococci embedded within biofilm 1.
Ceftazidime, gentamicin, or ciprofloxacin can be used for treatment of gram-negative microorganisms 1.
Antibiotic lock solutions, such as vancomycin, ceftazidime, or cefazolin, can be used to treat catheter-related bloodstream infections 1.
The duration of therapy for device-related infections depends on the complexity of the infection and the patient's response to treatment, ranging from 10-14 days for uncomplicated bacteremia to 4-6 weeks for complicated infections 1.

From the Research

The incidence of phlebitis varies among different antibiotics, with some antibiotics having a higher tendency to cause phlebitis than others 2.
Dicloxacillin and erythromycin have been found to have the greatest tendency to cause phlebitis, while ampicillin, imipenem/cilastatin, clindamycin, netilmicin, and vancomycin are not associated with a higher risk of phlebitis 2.
The physicochemical characteristics of antimicrobials, such as pH, osmolarity, and vesicant properties, can influence the risk of phlebitis and other complications associated with intravenous administration 3.

Prevention of phlebitis is crucial, and measures such as selecting the appropriate material for venous catheterization, choosing the correct site of injection, and observing strict surgical asepsis can help reduce the risk of phlebitis 4.
The use of specific antibiotic treatments, such as vancomycin, can also help prevent phlebitis, especially when administered using guidelines designed to prevent phlebitis 5.
In cases where phlebitis occurs, treatment may involve withdrawing the material that caused the thrombophlebitis, instituting specific antibiotic treatment, and possibly performing surgical ligation of the affected vein 4.

The site of insertion and age of the patient can also influence the risk of phlebitis, with certain sites and age groups being more prone to phlebitis 2.
Medications such as warfarin may have a protective effect against phlebitis, while treatment with low molecular weight heparin may reduce the risk of phlebitis, although the difference may not be significant 2.
The day-specific risk of phlebitis may increase between days 1 and 2 of antibiotic administration, but may not continue to increase on subsequent days 2.