From the Guidelines
It is safe to take magnesium at the same time as Crestor (rosuvastatin), but it's best to separate them by at least 2 hours to maximize the effectiveness of both. Taking them together may potentially reduce the absorption of Crestor, making it less effective at lowering cholesterol. Magnesium supplements can bind to certain medications in the digestive tract, forming complexes that are harder for your body to absorb.
Key Considerations
- The provided evidence does not directly address the interaction between magnesium and Crestor (rosuvastatin) 1.
- However, it discusses the importance of considering drug-drug interactions when taking statins, such as Crestor, with other medications or supplements.
- The evidence highlights the potential for certain substances to affect the absorption or efficacy of statins, which could be relevant to the interaction between magnesium and Crestor.
Recommendations
- If you need to take both magnesium and Crestor, consider taking Crestor in the evening as typically prescribed, and your magnesium supplement in the morning with food.
- This timing helps maximize the effectiveness of both.
- Always inform your healthcare provider about all supplements you're taking alongside prescription medications, as they can provide personalized advice based on your specific health situation and medication regimen.
- If you experience any unusual side effects when taking these together, contact your healthcare provider promptly.
Important Notes
- The American Heart Association and other organizations provide guidelines for managing patients with chronic coronary disease, including recommendations for statin use and potential drug-drug interactions 1.
- While these guidelines do not specifically address the interaction between magnesium and Crestor, they emphasize the importance of careful consideration and monitoring when taking multiple medications or supplements.
From the FDA Drug Label
Concomitant Use of Antacids When taking rosuvastatin with an aluminum and magnesium hydroxide combination antacid, administer rosuvastatin tablets at least 2 hours before the antacid [see Drug Interactions (7. 2)]. It is not recommended to take magnesium at the same time as Crestor (rosuvastatin), as the drug label advises administering rosuvastatin tablets at least 2 hours before an aluminum and magnesium hydroxide combination antacid 2.
From the Research
Interaction between Magnesium and Crestor (Rosuvastatin)
- The interaction between magnesium and Crestor (rosuvastatin) is not directly addressed in studies 3, 4, which focus on the efficacy and safety of rosuvastatin in managing dyslipidemia and its effect on atherosclerosis.
- However, a study 5 investigated the chemical stability of cholesterol-lowering drugs, including rosuvastatin, in a simple co-suspension with magnesium oxide. The results showed that rosuvastatin was stable in the co-suspension, but its recovery decreased significantly after 5 hours.
- Another study 6 examined the effect of an antacid preparation containing aluminium hydroxide and magnesium hydroxide on rosuvastatin pharmacokinetics. The results showed that simultaneous administration of the antacid and rosuvastatin reduced the systemic exposure of rosuvastatin by approximately 50%.
- A review 7 discussed the link between magnesium supplements and statin medication in dyslipidemic patients, highlighting the potential benefits of combining magnesium intake with statin therapy in preventing chronic metabolic problems.
Safety of Taking Magnesium with Crestor (Rosuvastatin)
- Based on the available evidence 5, 6, it appears that taking magnesium with Crestor (rosuvastatin) may not be entirely safe, as it may affect the stability and pharmacokinetics of the drug.
- However, the exact nature and extent of this interaction are not fully understood and require further investigation.
- It is essential to consult with a healthcare professional before taking magnesium supplements with Crestor (rosuvastatin) or any other medication.