What is the most effective Non-Steroidal Anti-Inflammatory Drug (NSAID) for the treatment of endometriosis?

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Last updated: March 12, 2025 • View editorial policy

From the Research

Naproxen (Aleve) is the most effective Non-Steroidal Anti-Inflammatory Drug (NSAID) for the treatment of endometriosis, typically taken at 500mg twice daily with food, as it has been shown to reduce prostaglandin production, which drives inflammation and pain in endometriosis tissue 1. The use of NSAIDs, such as naproxen, is a common first-line treatment for managing pain associated with endometriosis.

  • NSAIDs work by reducing prostaglandin production, which drives inflammation and pain in endometriosis tissue.
  • Naproxen and ibuprofen are the most commonly used NSAIDs for endometriosis pain management.
  • These medications are most effective when taken before pain becomes severe, such as at the first sign of menstrual symptoms.
  • For maximum benefit, they should be taken consistently rather than as needed.
  • Side effects may include stomach irritation, so taking them with food is recommended.
  • If one NSAID doesn't provide adequate relief after a few cycles, trying a different one may help.
  • While NSAIDs can help manage symptoms, they don't treat the underlying condition, so combining them with hormonal treatments prescribed by a healthcare provider often provides better long-term management of endometriosis 2, 3, 4. It's essential to note that the quality of evidence for NSAIDs in endometriosis management is very low, and more research is needed to determine their effectiveness 1. However, based on the available evidence and clinical guidelines, naproxen is considered a suitable option for managing endometriosis pain, and its use should be tailored to individual patient needs and preferences 4.

References

Research

Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis.

The Cochrane database of systematic reviews, 2017

Research

Medical treatment of endometriosis-related pain.

Best practice & research. Clinical obstetrics & gynaecology, 2018

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