What is the recommended dose of Mucinex (Guaifenesin) for adults and children?

Guaifenesin Dosage Recommendations for Adults and Children

The recommended dose of Mucinex (guaifenesin) for adults and children 12 years and over is 10-20 mL (2-4 teaspoons) every 4 hours, not exceeding 6 doses in 24 hours. For immediate-release formulations, extended-release tablets offer a convenient 12-hour dosing alternative 1, 2.

Adult Dosing

• Adults and children 12 years and over:
  • 10-20 mL (2-4 teaspoons) every 4 hours, not exceeding 6 doses in 24 hours 1
  • Extended-release formulation: 1,200 mg (two 600 mg tablets) every 12 hours 2

Pediatric Dosing

Dosing varies by age group:

• Children 6 to under 12 years: 5-10 mL (1-2 teaspoons) every 4 hours 1
• Children 2 to under 6 years: 2.5-5 mL (½-1 teaspoon) every 4 hours 1
• Children under 2 years: Consult a physician 1

According to the American Academy of Pediatrics, children 2-5 years old should not exceed 600 mg of guaifenesin in 24 hours 3.

Administration Guidelines

• Liquid/syrup formulations are typically preferred for young children
• Use calibrated medication syrup or cup for accurate measurement, especially for children 3
• Extended-release tablets should not be crushed or chewed
• May be taken with or without food, though taking with food may improve gastrointestinal tolerability 2

Duration of Treatment

• Limit treatment to 7 days unless otherwise directed by a healthcare provider 3
• Discontinue use and consult a healthcare provider if symptoms worsen or persist beyond 7 days 3

Safety Considerations

• Guaifenesin has a well-established safety profile in both adult and pediatric populations 4
• Common side effects include gastrointestinal disturbances (nausea, vomiting, stomach pain) and dizziness 5
• Ensure adequate hydration during treatment to help thin mucus secretions 3
• In rare cases, high doses may cause central nervous system depression 6

Formulation Options

• Immediate-release: Requires dosing every 4 hours due to short half-life 2
• Extended-release: Provides 12-hour coverage, improving convenience and compliance 2, 5

Common Errors to Avoid

• Using adult formulations for children
• "Eyeballing" doses without proper measurement tools
• Using combination products that may lead to overdosing of certain components 3
• Extended use beyond recommended duration without medical supervision

Guaifenesin is considered safe and effective for the treatment of mucus-related symptoms in acute upper respiratory tract infections when used at appropriate doses 4.