From the FDA Drug Label
Food Interaction: Oral administration of perindopril erbumine tablets with food does not significantly lower the rate or extent of perindopril absorption relative to the fasted state Food does not alter the pharmacokinetics of nebivolol. Under fed conditions, nebivolol glucuronides are slightly reduced. Nebivolol tablets may be administered without regard to meals.
- Perindopril: can be taken with or without food, as food does not significantly affect its absorption.
- Nebivolol: can be taken with or without food, as food does not alter its pharmacokinetics.
- Amlodipine, Famotidine, and Methylphenidate: The FDA drug label does not answer the question.
From the Research
Coveram, Nebil, Famotin, and Ritalin have different recommendations regarding food intake, with the most recent evidence suggesting that Coveram can be taken with or without food, Nebil can be taken with or without food, Famotin works best on an empty stomach, and Ritalin is typically recommended to be taken with or after meals to reduce stomach upset. The recommendations for taking these medications with or without food are based on their pharmacokinetic properties and potential for food-drug interactions, as discussed in a review of food-drug interactions on oral drug absorption 1.
- Key considerations for each medication include:
- Coveram (perindopril/amlodipine): can be taken with or without food, preferably in the morning before breakfast, as its absorption is not significantly affected by food intake 2.
- Nebil (nebivolol): can be taken with or without food, though consistent timing is important to maintain steady blood levels.
- Famotin (famotidine): works best when taken on an empty stomach, about 30-60 minutes before meals or at bedtime, to optimize its absorption and efficacy.
- Ritalin (methylphenidate): is typically recommended to be taken with or after meals to reduce stomach upset and help maintain consistent absorption, although taking it with food, especially fatty food, may slightly delay but not reduce its absorption 3. It's essential to follow a consistent routine regarding food intake to maintain steady blood levels and minimize potential gastrointestinal side effects, as highlighted in a study on the effects of food on bioavailability of analgesics 3. Additionally, if you experience stomach upset with any medication, taking it with a light meal might help reduce gastrointestinal side effects, as discussed in a review of gastrointestinal side effects associated with antidepressant treatments 4. Always follow your doctor's specific instructions, as they may have tailored recommendations based on your individual health needs and other medications you may be taking.