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Last updated: September 2, 2025View editorial policy

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Differential Diagnosis for Dizziness upon Standing

  • Single most likely diagnosis
    • Orthostatic hypotension: This condition is characterized by a significant drop in blood pressure when standing up, leading to dizziness or lightheadedness. It is a common cause of dizziness upon standing, especially in the elderly or those with dehydration, blood loss, or certain medications.
  • Other Likely diagnoses
    • Dehydration: Inadequate fluid intake or excessive fluid loss can lead to dehydration, causing dizziness when standing due to decreased blood volume and subsequent drop in blood pressure.
    • Anemia: A decrease in red blood cells or hemoglobin can reduce oxygen delivery to tissues, including the brain, leading to dizziness upon standing.
    • Medication side effects: Certain medications, such as antihypertensives, diuretics, and sedatives, can cause dizziness when standing due to their effects on blood pressure, fluid balance, or the central nervous system.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Cardiac conditions (e.g., arrhythmias, heart failure): Although less common, cardiac issues can cause dizziness upon standing due to inadequate cardiac output or abnormal heart rhythms.
    • Neurological disorders (e.g., multiple system atrophy, Parkinson's disease): Certain neurological conditions can affect blood pressure regulation, leading to orthostatic hypotension and dizziness upon standing.
    • Severe blood loss or internal bleeding: Significant blood loss can cause dizziness upon standing due to decreased blood volume and subsequent drop in blood pressure.
  • Rare diagnoses
    • Postural orthostatic tachycardia syndrome (POTS): A rare condition characterized by a rapid heart rate and other symptoms that occur upon standing, including dizziness.
    • Autonomic nervous system disorders (e.g., pure autonomic failure): Rare conditions that affect the autonomic nervous system, leading to abnormal blood pressure regulation and dizziness upon standing.
    • Endocrine disorders (e.g., adrenal insufficiency): Certain endocrine conditions can cause dizziness upon standing due to abnormalities in blood pressure regulation or electrolyte balance.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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