What is the best option to optimize therapy for a 73-year-old woman with permanent atrial fibrillation (AF) and heart failure with reduced ejection fraction (HFrEF), currently on sacubitril/valsartan (Angiotensin Receptor-Neprilysin Inhibitor), carvedilol (Beta-Blocker), aspirin (Acetylsalicylic Acid), and dapagliflozin (Sodium-Glucose Cotransporter 2 Inhibitor)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board

Educational purpose only • Exercise caution as content is pending human review

Article Review Status

Submitted

Under Review

Approved

Last updated: September 3, 2025 • View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Related Questions

Can any heart failure medications be stopped in a patient with improved ejection fraction (EF) on metoprolol succinate, sacubitril/valsartan (Entresto), spironolactone (Aldactone), and dapagliflozin (Farxiga)?

What can be done in primary care for an elderly female patient on valsartan (valsartan) 160 mg with persistent bradycardia, currently presenting with a heart rate of 47, after two weeks of low heart rates in the 40's?

What treatment adjustment is recommended for a 62-year-old female with hypothyroidism, hypertension, and heart failure with improved ejection fraction, currently experiencing New York Heart Association (NYHA) Class II symptoms, and taking sacubitril/valsartan (valsartan and sacubitril) 49 mg/51 mg orally twice daily, carvedilol 25 mg orally twice daily, and furosemide (frusemide) 40 mg orally daily, to reduce her risk of heart failure rehospitalization and cardiovascular death?

What are the contraindications for using Selective Serotonin Reuptake Inhibitors (SSRIs) or Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) in a patient with chronic heart disease, reduced ejection fraction, pacemaker with Implantable Cardioverter-Defibrillator (ICD), and currently taking Entresto (sacubitril/valsartan), Farxiga (dapagliflozin), Coreg (carvedilol), Spironolactone, and Atorvastatin?

What intervention improves survival in a 69-year-old female with a history of chronic hypertension, previous myocardial infarction (MI), left ventricular ejection fraction (LVEF) of 32%, and symptoms of heart failure, currently treated with aspirin (acetylsalicylic acid), atorvastatin, Lasix (furosemide), Lisinopril (Lisipril), and Toprol XL (metoprolol succinate)?

What type of transporters are responsible for carbohydrate absorption in intestinal cells?

What are the key points to cover when presenting on abdominal aortic aneurysm (AAA) repair to a surgery attending?

Why would a dry powder inhaler (DPI) with inhaled corticosteroid (ICS)/formoterol be beneficial for as-needed symptoms in a patient with asthma who uses albuterol by metered dose inhaler (MDI) incorrectly?

What are the effects of lead poisoning on the body and how is it treated?

Can prazosin treat extrapyramidal symptoms (EPS)?

How does lead cause anemia?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.