From the FDA Drug Label
Doxycycline is also indicated for the treatment of infections caused by the following gram-negative microorganisms: ... Cholera caused by Vibrio cholerae (formerly Vibrio comma).
Key points:
- Doxycycline is indicated for the treatment of cholera caused by Vibrio cholerae.
- The FDA label does not provide information on the treatment of other Vibrio species.
The antibiotic doxycycline treats Vibrio cholerae infections, which is a type of Vibrio infection 1.
From the Research
Vibrio infections should be treated with ciprofloxacin as the first-line antibiotic, given its sustained efficacy and low resistance rates, as demonstrated in the most recent study 2.
Treatment Options
- For mild to moderate infections, ciprofloxacin (500 mg twice daily for 7-10 days) is recommended.
- Severe infections may require intravenous antibiotics like ceftriaxone (1-2 g daily) or cefotaxime (1-2 g every 8 hours).
- Combination therapy with doxycycline plus either ceftazidime or cefotaxime may also be considered for Vibrio vulnificus infections.
Key Considerations
- Prompt antibiotic treatment is crucial to prevent serious complications, especially in patients with seafood allergies or those who have been exposed to contaminated seawater with open wounds.
- Supportive care and sometimes surgical debridement may be necessary alongside antibiotic therapy for severe infections.
- The choice of antibiotic should be guided by the most recent susceptibility data, with ciprofloxacin being a reliable option due to its low resistance rates 2.
Evidence Summary
- A 2024 study found that all Vibrio isolates were susceptible to ciprofloxacin, indicating its sustained efficacy as a first-line agent in the treatment of severe vibriosis 2.
- Another study from 2024 established clinical breakpoints for various antibiotics, including ciprofloxacin, against Vibrio species 3.
- A 2019 study compared the outcomes of patients treated with third-generation cephalosporin plus ciprofloxacin or doxycycline and found no significant difference in survival rates between the two groups 4.