Multiple Sclerosis (MS): This is a condition that affects the brain and spinal cord, leading to symptoms such as numbness, weakness, and vision problems. The presentation of numbness in a non-dermatomal pattern (affecting areas not corresponding to a specific nerve root) and the involvement of multiple limbs could suggest MS, especially if there are other symptoms like optic neuritis, diplopia, or ataxia.

Peripheral Neuropathy: Conditions like diabetes, vitamin deficiencies (especially B12), or alcohol abuse can cause peripheral neuropathy, leading to numbness in the hands and feet. The pattern of numbness can be symmetrical or asymmetrical.
Radial and Peroneal Neuropathy: Direct compression or injury to the radial nerve (affecting the hand) and peroneal nerve (affecting the lower leg) could explain the symptoms, though this would be less common to present simultaneously without a clear history of trauma or compression.
Vitamin B12 Deficiency: A deficiency in vitamin B12 can cause neurological symptoms including numbness in the hands and feet, making it a plausible diagnosis if the patient has a history of poor diet, malabsorption, or certain medications.

Spinal Cord Compression: This is a medical emergency that can present with numbness, weakness, and loss of bladder or bowel control. Causes include tumors, abscesses, or fractures. Prompt diagnosis and treatment are crucial to prevent permanent neurological damage.
Stroke or Transient Ischemic Attack (TIA): Although less likely given the duration and nature of symptoms, a stroke or TIA could present with sudden onset of numbness. However, these conditions typically involve more acute presentations and may include other symptoms like facial weakness, speech difficulties, or visual disturbances.
Cervical Spondylotic Myelopathy: This condition involves compression of the spinal cord in the neck, leading to a range of neurological symptoms including numbness, weakness, and difficulty with coordination and balance.

Sjögren's Syndrome: An autoimmune disorder that can cause peripheral neuropathy among other symptoms, though it is less common and typically associated with dry eyes and mouth.
Lyme Disease: Neurological manifestations of Lyme disease can include neuropathy, though this would be unusual without other systemic symptoms or a history of tick exposure.
Vasculitis: Certain types of vasculitis, like polyarteritis nodosa or giant cell arteritis, can cause neuropathy, but these conditions are rare and usually present with systemic symptoms such as fever, weight loss, and malaise.