What is the recommended interval between the two doses of Trumenba (Meningococcal B vaccine)?

Trumenba (MenB-FHbp) Vaccine Dosing Interval

For Trumenba (MenB-FHbp) vaccine, the two doses should be administered at 0 and 6 months in healthy adolescents and young adults who are not at increased risk for meningococcal disease. 1

Dosing Schedules Based on Risk Status

Standard Two-Dose Schedule (Healthy Individuals)

• Target population: Healthy adolescents and young adults aged 16-23 years (preferred age 16-18 years)
• Dosing interval: 0 and 6 months
• Important note: If the second dose is administered earlier than 6 months after the first dose, a third dose must be given at least 4 months after the second dose 1, 2

Three-Dose Schedule (High-Risk Individuals)

• Target population: Persons aged ≥10 years at increased risk for meningococcal disease
• Dosing interval: 0,1-2, and 6 months
• High-risk conditions include:
  • Persistent complement component deficiencies
  • Taking complement inhibitors
  • Anatomic or functional asplenia
  • Microbiologists exposed to Neisseria meningitidis
  • Persons during serogroup B meningococcal disease outbreaks 1

Key Considerations

Minimum Intervals

• The minimum interval between any two doses of MenB vaccine is 4 weeks 1
• The same product must be used for all doses in a series - Trumenba and Bexsero are not interchangeable 1

Vaccine Administration

• Administer as a 0.5-mL intramuscular injection
• May be administered with other age-appropriate vaccines at different anatomic sites 1

Persistence of Immunity

• Immune responses decline after primary vaccination but remain higher than pre-vaccination levels for at least 48 months 3
• A booster dose given 48 months after primary vaccination elicits robust immune responses, indicating immunologic memory 3
• Consider a booster dose for individuals at continued risk of invasive meningococcal disease 3, 1

Common Adverse Reactions

• Pain at injection site (most common)
• Fatigue
• Headache
• Myalgia
• Chills

Practical Recommendations

1. For healthy adolescents, follow the 0 and 6 months schedule
2. For high-risk individuals, use the three-dose schedule (0,1-2, and 6 months)
3. Document the specific MenB vaccine used (Trumenba) to ensure the same product is used for all doses
4. If the second dose is given earlier than 6 months after the first dose, plan for a third dose at least 4 months after the second dose
5. Consider a booster dose for individuals with ongoing risk factors

The 2017 ACIP recommendations specifically state that for low-risk adolescents, serogroup B meningococcal vaccine may be given as a two-dose series 4, which has been further clarified in more recent guidelines to be at 0 and 6 months for Trumenba 1, 5.