From the Research
High estradiol levels can cause several noticeable symptoms in both men and women, including breast tenderness or enlargement, water retention and bloating, mood swings, irritability, anxiety, headaches, decreased sex drive, and irregular menstrual cycles in women. These symptoms occur because estradiol, the most potent form of estrogen, affects multiple body systems including reproductive organs, brain function, cardiovascular health, and fat distribution. Elevated levels disrupt the normal hormonal balance, particularly the estrogen-to-testosterone ratio. Some of the most recent studies have highlighted the impact of estradiol on mental health, with a study from 1 showing that mood sensitivity to estradiol predicts depressive symptoms in the menopause transition. Additionally, high estradiol levels have been linked to an increased risk of certain cancers, such as ovarian and ER-positive breast cancer, as shown in a study from 2. Other symptoms that may be associated with high estradiol levels include:
- Heavy menstrual bleeding
- Weight gain, particularly around the hips and thighs
- Increased risk of blood clots
- Decreased muscle mass, erectile dysfunction, and infertility in men
- Delirium in elderly women, as shown in a study from 3 If you experience these symptoms, consult a healthcare provider who can order blood tests to measure hormone levels and determine appropriate treatment, which might include lifestyle modifications, medication adjustments, or addressing underlying conditions like polycystic ovary syndrome, certain tumors, or liver disease that may be causing the elevation. It is essential to note that the measurement of estradiol levels can be affected by various factors, including the type of assay used, as highlighted in a study from 4. Therefore, it is crucial to use accurate and reliable methods to measure estradiol levels and to interpret the results in the context of the individual's overall health and medical history.