Gastroesophageal Reflux Disease (GERD) with Skin Manifestation: The combination of stomach unease and GERD symptoms, along with itchy burning skin, could be related to the reflux of stomach acid causing skin irritation or an allergic reaction to food that also triggers GERD.

Atopic Dermatitis (Eczema): This condition can cause itchy, burning skin and is sometimes associated with gastrointestinal issues, including GERD, due to shared allergic or immune system dysregulation mechanisms.
Food Allergy or Intolerance: Certain foods can trigger both skin reactions (like hives or eczema) and gastrointestinal symptoms, including GERD, making this a plausible explanation for the combination of symptoms.
Irritable Bowel Syndrome (IBS): While primarily affecting bowel habits, IBS can also lead to stomach unease and, in some cases, skin symptoms due to the gut-skin axis, where gut health influences skin health.

Celiac Disease: An autoimmune reaction to gluten that can cause skin lesions (dermatitis herpetiformis), gastrointestinal symptoms, and potentially lead to severe complications if not diagnosed and managed with a gluten-free diet.
Hepatic or Biliary Disease: Certain liver or bile duct conditions can cause skin itching (pruritus) and gastrointestinal symptoms, including those mimicking GERD. Missing these diagnoses could lead to severe liver damage or other complications.
Thyroid Disorders: Both hyperthyroidism and hypothyroidism can cause skin symptoms (including itching and burning) and gastrointestinal issues, including reflux symptoms. These conditions require timely diagnosis and treatment to prevent long-term health consequences.

Mastocytosis: A condition characterized by the accumulation of mast cells in one or more organs, which can lead to a variety of symptoms, including skin lesions, gastrointestinal symptoms, and potentially GERD-like symptoms due to histamine release.
Sjögren's Syndrome: An autoimmune disorder that can cause skin symptoms, gastrointestinal issues, and potentially lead to complications like esophageal dysmotility, which might be mistaken for GERD.
Eosinophilic Esophagitis: A chronic immune system disease in which a type of white blood cell, the eosinophil, builds up in the esophagus in response to an allergen or irritant, leading to symptoms that can overlap with GERD and potentially cause skin manifestations in the context of an allergic reaction.