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Last updated: September 4, 2025View editorial policy

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Differential Diagnosis for Radicular Pain

  • Single most likely diagnosis
    • Herniated disk: This is the most common cause of radicular pain, especially in the lower back. It occurs when the soft inner gel of the disk leaks out through a tear in the outer layer, putting pressure on the spinal nerves and causing pain that radiates down the arm or leg.
  • Other Likely diagnoses
    • Spondylosis: This refers to degenerative changes in the spine, such as osteoarthritis, which can cause radicular pain by narrowing the spaces through which nerves exit the spine.
    • Spinal stenosis: A narrowing of the spinal canal, which can put pressure on the spinal cord and nerves, leading to radicular pain.
    • Osteoporotic compression fracture: Weakened bones can lead to fractures, which may compress nerves and cause radicular pain.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Cauda equina syndrome: A serious condition that occurs when the nerves in the spinal canal are compressed, leading to loss of bladder and bowel control, among other symptoms. It requires immediate medical attention.
    • Spinal infection (e.g., abscess or osteomyelitis): Infections in the spine can cause severe pain and neurological deficits, and if not treated promptly, can lead to serious complications.
    • Spinal tumor: Both benign and malignant tumors can compress nerves and cause radicular pain. Early diagnosis is crucial for effective treatment.
  • Rare diagnoses
    • Arachnoiditis: Inflammation of the membranes surrounding the spinal cord, which can cause radicular pain and other neurological symptoms.
    • Tarlov cysts: Fluid-filled sacs that can compress nerves and cause radicular pain, though they are often asymptomatic.
    • Neurosyphilis: A complication of untreated syphilis that can cause a variety of neurological symptoms, including radicular pain, though it is relatively rare in areas with access to modern healthcare.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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