Formoterol Inhalers with Steroids for Asthma
Symbicort (budesonide/formoterol) is the primary formoterol-containing inhaler that includes a steroid component for asthma management. 1
Formoterol-Steroid Combination Products
Symbicort combines two essential medications for asthma management:
- Budesonide: An inhaled corticosteroid (ICS) that treats underlying airway inflammation
- Formoterol: A rapid- and long-acting beta2-agonist (LABA) that prevents and reverses airway obstruction 2
This combination provides complementary effects by addressing both major components of asthma pathophysiology:
- Inflammation (steroid component)
- Bronchoconstriction (formoterol component)
Dosage Forms and Strengths
Symbicort is available in:
- Turbuhaler (dry powder inhaler) in many countries outside the USA 2
- Pressurized metered-dose inhaler (pMDI) in the USA 3
- Standard strengths for adults and children ≥12 years: 80/4.5 mcg or 160/4.5 mcg (2 inhalations twice daily) 1
Clinical Efficacy
Symbicort has demonstrated superior efficacy compared to:
- Higher-dose corticosteroid monotherapy 2, 4
- Individual components administered via separate inhalers 2, 3
Key benefits include:
- Rapid onset of action (apparent within 1 minute of treatment) 4
- Long duration of effect allowing twice-daily dosing 2, 4
- Reduction in both moderate and severe exacerbations 5, 1
- Improved patient adherence due to convenience of a single inhaler 2
Role in Asthma Management
According to current guidelines, Symbicort is positioned as:
- A preferred treatment for moderate to severe persistent asthma (Steps 3-4 in the stepwise approach) 1
- An alternative to increasing the dose of inhaled corticosteroids when asthma is not adequately controlled on ICS alone 5
Unique Administration Approaches
Symbicort can be used in different dosing strategies:
- Fixed dosing: Standard twice-daily maintenance dosing
- Adjustable maintenance dosing: Allows dose adjustments based on symptom control, resulting in equivalent control with lower overall medication use 3, 4
- SMART therapy (Symbicort Maintenance And Reliever Therapy): Using the same inhaler for both maintenance and as-needed relief 6, 7
Important Cautions
- Formoterol should never be used as monotherapy for asthma due to increased risk of asthma-related death 1
- Patients should rinse their mouth after use to prevent localized Candida infections 1
- Not recommended for children under 6 years of age 1
Clinical Pearls
- The combination of budesonide and formoterol may have synergistic effects when administered in a single inhaler 4
- The rapid onset of formoterol makes this combination particularly beneficial for patients who need quick symptom relief 2, 4
- For children aged 6-11 years, dosage should be determined by the treating physician as studies with the pMDI formulation are limited for this age group 1
Symbicort represents an effective approach to asthma management by combining anti-inflammatory and bronchodilator effects in a single convenient device, improving both symptom control and patient adherence.