Daflon 500 mg Dosage for Internal Hemorrhoids in a 70-Year-Old Woman
For a 70-year-old woman with internal hemorrhoids, the recommended dosage of Daflon 500 mg is 2 tablets twice daily (2000 mg total daily dose) for 4 weeks, followed by a maintenance dose of 2 tablets once daily if needed for long-term management.
Initial Treatment Phase
The optimal dosing regimen for Daflon 500 mg (micronized purified flavonoid fraction) in treating internal hemorrhoids follows a two-phase approach:
Acute Phase (First 4 weeks):
- Dosage: 2 tablets (1000 mg) twice daily
- Duration: 4 weeks
- Total daily dose: 2000 mg
This intensive initial regimen has been shown to effectively reduce the frequency, duration, and intensity of hemorrhoidal symptoms in clinical studies 1, 2, 3.
Maintenance Phase (If needed):
- Dosage: 2 tablets (1000 mg) once daily
- Duration: As needed for symptom control
- Total daily dose: 1000 mg
Efficacy and Mechanism of Action
Daflon 500 mg contains 90% micronized diosmin and 10% hesperidin, which work by:
- Improving venous tone and lymphatic drainage
- Reducing capillary hyperpermeability
- Protecting microcirculation from inflammatory processes 1
Clinical studies have demonstrated that Daflon 500 mg significantly improves hemorrhoidal symptoms including:
The micronization of diosmin to particles <2 μm improves absorption and efficacy 1.
Considerations for Elderly Patients
For a 70-year-old patient, special attention should be paid to:
- Tolerability: Daflon has a safety profile similar to placebo in clinical trials, making it appropriate for elderly patients 1
- Potential drug interactions: Monitor for interactions with other medications commonly used by elderly patients
- Renal function: No specific dose adjustment is typically required, but monitoring is prudent
Complementary Management Approaches
While taking Daflon 500 mg, the following additional measures should be implemented:
- Dietary modifications: Increase fiber intake to 25-30g daily 4
- Hydration: Ensure adequate fluid intake
- Topical treatments: Consider low-potency topical corticosteroids (hydrocortisone 1%) for perianal irritation for up to 7 days if needed 4
- Sitz baths: 2-3 times daily to relieve discomfort 4
- Physical activity: Regular, gentle exercise to promote bowel regularity 4
- Avoid prolonged sitting: Especially on the toilet, to reduce pressure on hemorrhoids 4
Treatment Duration and Follow-up
- Initial evaluation: After 4 weeks of treatment
- Long-term management: Consider maintenance therapy of 2 tablets daily for 60-83 days if symptoms persist or recur 1
- Follow-up: Regular assessment to monitor symptom improvement and potential side effects
Potential Side Effects
The most common adverse events are mild and include:
- Gastrointestinal symptoms (mild digestive discomfort)
- Autonomic symptoms (rare)
These side effects are generally well-tolerated and rarely require discontinuation of treatment 1, 3.
When to Consider Alternative Treatments
If symptoms do not improve after 4 weeks of Daflon therapy, consider:
- Rubber band ligation for grade I-II hemorrhoids 4
- Surgical options for grade III-IV hemorrhoids if conservative measures fail 4
- Referral to a specialist for further evaluation
By following this treatment protocol with Daflon 500 mg, most patients with internal hemorrhoids can expect significant symptom improvement within the 4-week initial treatment period.