Differential Diagnosis for Recurrent Hearing Loss, Vertigo, Ear Fullness, and Genetic Condition

• Single Most Likely Diagnosis
  • Meniere's Disease: This condition is characterized by recurrent episodes of vertigo, hearing loss, ear fullness, and tinnitus. While it is not exclusively genetic, there is a known familial component, suggesting a possible genetic predisposition in some cases.
• Other Likely Diagnoses
  • Otosclerosis: A genetic condition that affects the middle ear, leading to hearing loss. It can also cause vertigo and ear fullness, although these symptoms are less common.
  • Cochlear Otosclerosis: Similar to otosclerosis but affects the inner ear, potentially causing the symptoms described.
• Do Not Miss Diagnoses
  • Acoustic Neuroma: Although not typically genetic, a small percentage of cases are associated with Neurofibromatosis Type 2, a genetic disorder. It can cause hearing loss, vertigo, and ear fullness, making it crucial not to miss due to its potential for serious complications if left untreated.
  • Inner Ear Malformations: Certain genetic conditions can lead to malformations of the inner ear, which might present with the described symptoms.
• Rare Diagnoses
  • Usher Syndrome: A rare genetic disorder that causes hearing loss and vision loss. Some types can lead to vertigo and balance problems.
  • Pendred Syndrome: A genetic disorder that causes early hearing loss and vertigo, often associated with thyroid abnormalities. It's a rare condition but should be considered in the differential diagnosis due to its genetic nature and matching symptoms.