Differential Diagnosis for Eosinophilia, Endocardial Fibrosis, Mural Thrombus, and Left Ventricular Wall Thickness
Single Most Likely Diagnosis
- Hypereosinophilic Syndrome (HES): This condition is characterized by persistent eosinophilia, which can lead to end-organ damage, including the heart. The eosinophilic infiltration can cause endocardial fibrosis, mural thrombi, and increased left ventricular wall thickness due to fibrosis and inflammation.
Other Likely Diagnoses
- Loeffler's Endocarditis: A form of hypereosinophilic syndrome that specifically affects the heart, leading to endocardial fibrosis and thrombus formation.
- Tropical Endomyocardial Fibrosis (TEF): A condition prevalent in tropical regions, characterized by fibrosis of the endocardium, often associated with eosinophilia. It can lead to mural thrombi and increased ventricular wall thickness.
- Eosinophilic Granulomatosis with Polyangiitis (EGPA): A vasculitis that can involve the heart, leading to eosinophilia, endocardial fibrosis, and potentially mural thrombi.
Do Not Miss Diagnoses
- Acute Coronary Syndrome: Although less directly related to eosinophilia, conditions like myocardial infarction can lead to mural thrombus formation and changes in ventricular wall thickness. It's crucial to rule out these life-threatening conditions.
- Infective Endocarditis: Can cause mural thrombi and may be associated with eosinophilia in some cases, especially if there's an allergic reaction to the infecting organism.
Rare Diagnoses
- Idiopathic Hypereosinophilic Syndrome with Cardiac Involvement: A rare condition where eosinophilia leads to cardiac damage without a known cause.
- Familial Hypereosinophilic Syndrome: A genetic form of HES, which can also lead to cardiac involvement.
- Eosinophilic Leukemia: A rare myeloproliferative disorder that can cause eosinophilia and potentially affect the heart.