From the FDA Drug Label
Directions Adults Take 1 capsule every 4 to 6 hours while symptoms persist. If pain or fever does not respond to 1 capsule, 2 capsules may be used, but do not exceed 6 capsules in 24 hours, unless directed by a doctor. The smallest effective dose should be used. The optimal dosage of glucosamine is 1 capsule every 4 to 6 hours, with a maximum of 6 capsules in 24 hours, unless directed by a doctor 1.
- The dose may be increased to 2 capsules if symptoms persist, but only under the guidance of a doctor.
- It is recommended to use the smallest effective dose.
From the Research
The optimal dosage of glucosamine for joint health is 1,500 mg per day, as supported by the most recent and highest quality study 2. This dosage can be taken all at once or divided into three 500 mg doses throughout the day. Glucosamine sulfate is generally considered the most effective form, though glucosamine hydrochloride is also available. Some key points to consider when taking glucosamine include:
- The benefits of glucosamine are not immediate and may take 4-8 weeks of consistent use to notice improvements in joint pain and function.
- Glucosamine is often combined with chondroitin (typically 1,200 mg daily) and sometimes MSM for enhanced effectiveness.
- These supplements work by potentially reducing inflammation and providing building blocks for cartilage repair.
- While generally considered safe, glucosamine may interact with blood thinners and could affect blood sugar levels in some people with diabetes.
- Side effects are usually mild and may include digestive discomfort.
- Before beginning supplementation, especially if you have existing health conditions or take other medications, consulting with a healthcare provider is advisable. It's also important to note that the quality of the glucosamine supplement can affect its efficacy, and some studies have shown that patent-protected formulations of glucosamine sulfate may be more effective than other forms 3, 4. However, a more recent study found that the effects of glucosamine sulfate on osteoarthritis-related pain and joint-space changes were small to moderate, and that larger doses may be needed to achieve significant benefits 2. Overall, the current evidence suggests that 1,500 mg of glucosamine per day is a reasonable dosage for joint health, but individual results may vary and more research is needed to fully understand the effects of glucosamine on osteoarthritis.