Hypocalcemia: This condition, characterized by low calcium levels in the blood, can cause peri-oral numbness or tingling due to its effect on nerve function. It's a common and relatively benign condition that can be easily diagnosed and treated.

Multiple Sclerosis: An autoimmune disease affecting the brain and spinal cord, multiple sclerosis can cause numbness in various parts of the body, including the peri-oral area, due to demyelination of nerve fibers.
Vitamin B12 Deficiency: A deficiency in vitamin B12 can lead to neurological symptoms, including numbness or tingling around the mouth, due to its crucial role in the synthesis of myelin.
Dental Problems: Issues such as tooth abscesses, gum disease, or dental procedures can cause localized numbness or pain in the peri-oral area.

Stroke or Transient Ischemic Attack (TIA): Although less common, sudden onset of peri-oral numbness could be a symptom of a stroke or TIA, especially if accompanied by other neurological deficits. Early recognition is critical for timely intervention.
Lyme Disease: In its early stages, Lyme disease can cause neurological symptoms, including numbness or tingling, although this is less common. Given its potential for serious long-term consequences if untreated, it should not be missed.

Sarcoidosis: A rare autoimmune disease that can affect various parts of the body, including the nervous system, leading to numbness or tingling sensations.
Peripheral Neuropathy: Certain types of peripheral neuropathy, which result from damage to the peripheral nerves, can cause numbness in specific areas, including the peri-oral region.
Tumors: Although extremely rare, tumors affecting the facial nerves or other structures in the head and neck region could potentially cause peri-oral numbness.