From the Research
Luteinizing hormone (LH) injections can increase antral follicle count (AFC) and anti-Müllerian hormone (AMH) levels, as evidenced by a recent study published in 2022 1.
Key Findings
- The study found that extended LH administration (ELHA) at a dose of 187.5 IU LH every day or 150 IU LH every other day increased serum AMH levels and AFC in two young women with hypothalamic amenorrhea.
- In one patient, AMH and AFC increased from 1.3 ng/ml and 8 to 2.3 ng/ml and 14 at the end of treatment, respectively.
- The study suggests that LH administration may contribute to a clinically evident increase in the functional ovarian reserve (AFC) and have a positive effect on the progression of follicles throughout the early stages of folliculogenesis.
Clinical Implications
- LH injections may be a useful treatment option for women with low AFC and AMH levels, particularly those with hypothalamic amenorrhea.
- The optimal dose and duration of LH administration require further study, but the current evidence suggests that a dose of at least 150-187.5 IU every day or every other day may be effective.
- Patients concerned about low AMH or AFC should discuss comprehensive fertility preservation or treatment options with their reproductive endocrinologist, including the potential benefits and risks of LH injections.
Limitations
- The current evidence is based on a small case series, and larger studies are needed to confirm the findings and establish the safety and efficacy of LH injections for this indication.
- The study did not compare the effects of LH injections to other treatments, such as follicle-stimulating hormone (FSH) or combination therapy.