From the Guidelines
L-methylfolate may be beneficial for individuals with Attention Deficit Hyperactivity Disorder (ADHD), particularly those with MTHFR gene variants, as it supports neurotransmitter production and may help alleviate symptoms. However, it is essential to note that L-methylfolate is not a first-line treatment for ADHD and should be used under the guidance of a healthcare provider. The relationship between L-methylfolate and ADHD is complex, and more research is needed to fully understand its effects. Some key points to consider:
- L-methylfolate works by converting homocysteine to methionine, which supports the synthesis of dopamine, norepinephrine, and serotonin, neurotransmitters often imbalanced in ADHD 1.
- A typical starting dose of L-methylfolate is 7.5-15 mg daily, which can be adjusted based on response [@Example@].
- L-methylfolate may interact with certain medications, including antidepressants and anticonvulsants, and should be used with caution [@Example@].
- Getting tested for MTHFR gene variants may help determine if an individual may benefit from L-methylfolate supplementation [@Example@].
- L-methylfolate should complement, not replace, conventional ADHD treatments like stimulants or behavioral therapy [@Example@]. It is crucial to consult with a healthcare provider before starting L-methylfolate, especially if taking other medications, to ensure safe and effective use. The most recent and highest-quality study on this topic is from 2022, which highlights the importance of individualized treatment approaches for ADHD and the need for further research on novel medications, including L-methylfolate 1. In conclusion, while L-methylfolate may be beneficial for some individuals with ADHD, it is essential to approach its use with caution and under the guidance of a healthcare provider.
From the Research
Relationship Between L-Methylfolate and ADHD
- The relationship between L-methylfolate and Attention Deficit Hyperactivity Disorder (ADHD) is complex and not fully understood, with limited research available 2.
- A study published in 2019 found that L-methylfolate supplementation had no significant effect on ADHD symptoms in adults, except for improvement in adaptive dimension of the ASR scale 2.
- The same study suggested that L-methylfolate may be associated with reduced efficacy of methylphenidate, a common medication used to treat ADHD 2.
- Another study published in 2021 discussed the role of folate and MTHFR polymorphisms in the treatment of depression, but did not specifically address ADHD 3.
- However, a study published in 2016 found that L-methylfolate therapy was effective in a complex psychiatric illness with MTHFR C677T genetic polymorphism, which may be relevant to ADHD comorbidities 4.
- A case study published in 2017 reported improved symptoms of aggression and disruptive behavior in a child with autism and MTHFR C677TT allele after L-methylfolate supplementation, which may have implications for ADHD treatment 5.
- A review published in 2008 discussed the connections between folate and depression, including the role of L-methylfolate in neurotransmitter biosynthesis, but did not specifically address ADHD 6.
Key Findings
- L-methylfolate supplementation may not have a significant effect on ADHD symptoms in adults 2.
- L-methylfolate may be associated with reduced efficacy of methylphenidate 2.
- Genetic polymorphisms, such as MTHFR C677T, may play a role in the effectiveness of L-methylfolate therapy 4.
- L-methylfolate may have potential benefits in treating comorbidities associated with ADHD, such as depression and autism 3, 5.