Differential Diagnosis for Delayed Meconium

• Single Most Likely Diagnosis
  • Cystic Fibrosis: This condition is known to cause intestinal obstruction due to thick, sticky meconium, leading to delayed passage. It's a common cause of meconium ileus, which presents as delayed meconium.
• Other Likely Diagnoses
  • Hirschsprung's Disease: A congenital condition characterized by the absence of ganglion cells in the distal bowel, leading to functional obstruction and delayed meconium passage.
  • Small Left Colon Syndrome: A condition where the left colon is underdeveloped, potentially causing delayed meconium.
  • Meconium Plug Syndrome: A condition where plugs of meconium obstruct the intestine, leading to delayed passage.
• Do Not Miss Diagnoses
  • Intestinal Atresia: A congenital obstruction of the intestine that can cause delayed meconium and is critical to diagnose early to prevent complications.
  • Necrotizing Enterocolitis: A severe condition that can cause bowel ischemia and necrosis, potentially presenting with delayed meconium.
• Rare Diagnoses
  • Congenital Hypothyroidism: Although rare, congenital hypothyroidism can cause delayed meconium passage due to its effects on gut motility.
  • Abdominal Wall Defects: Conditions like gastroschisis or omphalocele can cause delayed meconium due to intestinal malrotation or obstruction.